Heat shock proteins: the 'Swiss Army Knife' vaccines against cancers and infectious agents

被引：126

作者：

Srivastava, PK ^{[1
]}

Amato, RJ

机构：

[1] Univ Connecticut, Sch Med, Ctr Immunotherapy Canc & Infect Dis, Farmington, CT 06030 USA

[2] Baylor Coll Med, Scott Dept Urol, Houston, TX 77030 USA

来源：

VACCINE | 2001年 / 19卷 / 17-19期

关键词：

heat shock protiens; infectious diseases; cancer;

D O I：

10.1016/S0264-410X(00)00492-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The ability of heat shock proteins to: (a) chaperone peptides, including antigenic peptides: (b) interact with antigen presenting cells through a receptor: (c) stimulate antigen presenting cells to secrete inflammatory cytokines: and (d) mediate maturation of dendritic cells, makes them a one-stop shop for the immune system. These properties also permit the utilization of heat shock proteins for development of a new generation of prophylactic and therapeutic vaccines against cancers and infectious diseases. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2590 / 2597

页数：8

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