Novel cytotoxic polyprenylated xanthonoids from Garcinia gaudichaudii (Guttiferae)

被引：61

作者：

Cao, SG

Sng, VHL

Wu, XH

Sim, KY

Tan, BHK

Pereira, JT

Goh, SH

机构：

[1] Natl Univ Singapore, Dept Chem, Singapore 119260, Singapore

[2] Natl Univ Singapore, Dept Pharmacol, Singapore 119260, Singapore

[3] Forest Res Ctr, Sandakan, Sabah, Malaysia

来源：

TETRAHEDRON | 1998年 / 54卷 / 36期

关键词：

D O I：

10.1016/S0040-4020(98)00644-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cytotoxicity guided phytochemical analysis of the leaf extract of the Malaysian medicinal plant Garcinia gaudichaudii led to the isolation of 15 novel cytotoxic compounds, gaudichaudiones A - H (1, 2, 8 - 10 and 12), gaudichaudiic acids A - E (3 - 6), including the known morellic acid (7) and forbesione (11). All are mainly tetraprenylated xanthonoids but gaudichaudione H (12) is a novel bridgehead methoxylated triprenylated xanthonoid. The novel caged structures were determined by detailed NMR spectral analysis and the compounds were found to exhibit significant cytotoxicity against several cancer cell lines. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：10915 / 10924

页数：10

共 18 条

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