Nigranoic acid, a triterpenoid from Schisandra sphaerandra that inhibits HIV-1 reverse transcriptase

被引：147

作者：

Sun, HD

Qiu, SX

Lin, LZ

Wang, ZY

Lin, ZW

Pengsuparp, T

Pezzuto, JM

Fong, HHS

Cordell, GA

Farnsworth, NR

机构：

[1] UNIV ILLINOIS,COLL PHARM,DEPT MED CHEM & PHARMACOGNOSY,PROGRAM COLLABORAT RES PHARMACEUT SCI,CHICAGO,IL 60612

[2] CHINESE ACAD SCI,KUNMING INST BOT,LAB PHYTOCHEM,KUNMING 650204,YUNNAN,PEOPLES R CHINA

来源：

JOURNAL OF NATURAL PRODUCTS | 1996年 / 59卷 / 05期

关键词：

D O I：

10.1021/np960149h

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

An A ring-secocycloartene triterpenoid, nigranoic acid (3,4-secocycloarta-4(28),24-(Z)-diene-3, 26-dioic acid, (1) was isolated from the stems of Schisandra sphaerandra, a Chinese traditional medicinal plant. Its structure elucidation and unambiguous NMR spectral assignment were achieved by the combination of 1D- and 2D-NMR techniques with the aid of computer modeling. Nigranoic acid showed activity in several. anti-HIV reverse transcriptase and polymerase assays.

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页码：525 / 527

页数：3

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