Exploiting a basic chemosensitizing pharmacophore hypothesis. Part 1: Synthesis and biological evaluation of novel arylbromide and bicyclic chemosensitizers against drug-resistant malaria parasites

被引：10

作者：

Chouteau, F

Ramanitrahasimbola, D

Rasoanaivo, P

Chibale, K

机构：

[1] Inst Malgache Rech Appl, Lab Pharmacognosie Appl Maladies Infect, Antananarivo 101, Madagascar

[2] Univ Cape Town, Dept Chem, ZA-7701 Rondebosch, South Africa

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 12期

基金：

新加坡国家研究基金会;

关键词：

malaria; chloroquine; chemosensitizers;

D O I：

10.1016/j.bmcl.2005.04.033

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An exploratory series of novel arylbromide and bicyclic chemosensitizers (modulators) against chloroquine-resistant Plasinodium falciparum were designed and synthesized on the basis of a basic chemosensitizing pharmacophore hypothesis in malaria. ortho-Substituted bromo and biphenyl ether compounds displayed the best activity from the series. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：3024 / 3028

页数：5

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