Effects of growth hormone on lipid metabolism in humans

被引：65

作者：

Moller, N ^{[1
]}

Gjedsted, J ^{[1
]}

Gormsen, L ^{[1
]}

Fuglsang, J ^{[1
]}

Djurhuus, C ^{[1
]}

机构：

[1] Aarhus Univ, Inst Expt Res, Med Dept Endocrinol & Diabet M, DK-8000 Aarhus C, Denmark

来源：

GROWTH HORMONE & IGF RESEARCH | 2003年 / 13卷

关键词：

growth hormone; lipid metabolism; protein metabolism; glucose metabolism; insulin sensitivity;

D O I：

10.1016/S1096-6374(03)00048-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The most immediate effect of growth hormone (GH) administration in humans is a significant increase in free fatty acids after 1-2 h, reflecting stimulation of lipolysis and ketogenesis. This stimulation represents an important physiological adaptation to stress and fasting. When the capacity of GH to increase lipolysis is blocked, the protein-retaining and insulin-antagonistic effects of GH on glucose metabolism are either abolished or weakened dramatically, compatible with a key role for lipolysis in orchestrating the metabolic actions of GH. (C) 2003 Published by Elsevier Science Ltd.

引用

页码：S18 / S21

页数：4

共 46 条

[1] QUANTITATIVELY MINOR ROLE OF CARBOHYDRATE IN OXIDATIVE METABOLISM BY SKELETAL MUSCLE IN INTACT MAN IN THE BASAL STATE - MEASUREMENTS OF OXYGEN AND GLUCOSE UPTAKE AND CARBON DIOXIDE AND LACTATE PRODUCTION IN THE FOREARM [J].

ANDRES, R ;

CADER, G ;

ZIERLER, KL .

JOURNAL OF CLINICAL INVESTIGATION, 1956, 35 (06) :671-682

[2] IDENTIFICATION OF JAK2 AS A GROWTH-HORMONE RECEPTOR-ASSOCIATED TYROSINE KINASE [J].

ARGETSINGER, LS ;

CAMPBELL, GS ;

YANG, XN ;

WITTHUHN, BA ;

SILVENNOINEN, O ;

IHLE, JN ;

CARTERSU, C .

CELL, 1993, 74 (02) :237-244

[3] ALTERATIONS IN THE PULSATILE MODE OF GROWTH-HORMONE RELEASE IN MEN AND WOMEN WITH INSULIN-DEPENDENT DIABETES-MELLITUS [J].

ASPLIN, CM ;

FARIA, ACS ;

CARLSEN, EC ;

VACCARO, VA ;

BARR, RE ;

IRANMANESH, A ;

LEE, MM ;

VELDHUIS, JD ;

EVANS, WS .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1989, 69 (02) :239-245

[4] EFFECTS OF GROWTH-HORMONE ON FUEL UTILIZATION AND MUSCLE GLYCOGEN-SYNTHASE ACTIVITY IN NORMAL HUMANS [J].

BAK, JF ;

MOLLER, N ;

SCHMITZ, O .

AMERICAN JOURNAL OF PHYSIOLOGY, 1991, 260 (05) :E736-E742

[5] GROWTH-HORMONE HETEROGENEITY - GENES, ISOHORMONES, VARIANTS, AND BINDING-PROTEINS [J].

BAUMANN, G .

ENDOCRINE REVIEWS, 1991, 12 (04) :424-449

[6] METABOLIC EFFECTS OF HUMAN AND MONKEY GROWTH HORMONE IN MAN [J].

BECK, JC ;

MCGARRY, EE ;

DYRENFURTH, I ;

VENNING, EH .

SCIENCE, 1957, 125 (3253) :884-885

[7] ROLE OF GH IN REGULATING NOCTURNAL RATES OF LIPOLYSIS AND PLASMA MEVALONATE LEVELS IN NORMAL AND DIABETIC HUMANS [J].

BOYLE, PJ ;

AVOGARO, A ;

SMITH, L ;

BIER, DM ;

PAPPU, AS ;

ILLINGWORTH, DR ;

CRYER, PE .

AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 263 (01) :E168-E172

[8] THE EFFECT OF GROWTH-HORMONE ON GLUCOSE-METABOLISM AND INSULIN-SECRETION IN MAN [J].

BRATUSCHMARRAIN, PR ;

SMITH, D ;

DEFRONZO, RA .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1982, 55 (05) :973-982

[9] Effects of growth hormone treatment on visceral adipose tissue [J].

Brummer, RJM .

GROWTH HORMONE & IGF RESEARCH, 1998, 8 :19-23

[10] Effects of pulsatile delivery of basal growth hormone on lipolysis in humans [J].

Cersosimo, E ;

Danou, F ;

Persson, M ;

Miles, JM .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 1996, 271 (01) :E123-E126

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