Sfh-1, a subclass B2 metallo-β-lactamase from a Serratia fonticola environmental isolate

被引：64

作者：

Saavedra, MJ

Peixe, L

Sousa, JC

Henriques, I

Alves, A

Correia, A ^{[1
]}

机构：

[1] Univ Aveiro, Dept Biol, Ctr Cell Biol, P-3810193 Aveiro, Portugal

[2] Univ Tras Montes & Alto Douro, ICETA, Dept Higiene & Sanidade, Vila Real, Portugal

[3] Univ Porto, Fac Pharm, P-4100 Oporto, Portugal

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 07期

关键词：

D O I：

10.1128/AAC.47.7.2330-2333.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

An environmental isolate of Serratia fonticola resistant to carbapenems was shown to contain a genetic determinant encoding a metallo-beta-lactamase of the subclass B2. The Sfh-I enzyme exhibits some divergence from the previously characterized enzymes of this subclass. This is the first example of a naturally occurring metallo-beta-lactamase in Enterobacteriaceae.

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页码：2330 / 2333

页数：4

相关论文

共 18 条

[1]

ALTSCHUL SF, 1990, J MOL BIOL, V215, P403, DOI 10.1006/jmbi.1990.9999

[2] THE STRUCTURE OF BETA-LACTAMASES [J].

AMBLER, RP .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 1980, 289 (1036) :321-331

[3] A FUNCTIONAL CLASSIFICATION SCHEME FOR BETA-LACTAMASES AND ITS CORRELATION WITH MOLECULAR-STRUCTURE [J].

BUSH, K ;

JACOBY, GA ;

MEDEIROS, AA .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (06) :1211-1233

[4] CAU-1, a subclass B3 metallo-β-lactamase of low substrate affinity encoded by an ortholog present in the Caulobacter crescentus chromosome [J].

Docquier, JD ;

Pantanella, F ;

Giuliani, F ;

Thaller, MC ;

Amicosante, G ;

Galleni, M ;

Frère, JM ;

Bush, K ;

Rossolini, GM .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (06) :1823-1830

[5] Standard numbering scheme for class B β-lactamases [J].

Galleni, M ;

Lamotte-Brasseur, J ;

Rossolini, GM ;

Spencer, J ;

Dideberg, O ;

Frère, JM .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (03) :660-663

[6]

Grimont P.A.D., 1984, BERGEYS MANUAL SYSTE, P477

[7] PCR MAPPING OF INTEGRONS REVEALS SEVERAL NOVEL COMBINATIONS OF RESISTANCE GENES [J].

LEVESQUE, C ;

PICHE, L ;

LAROSE, C ;

ROY, PH .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (01) :185-191

[8] THE AEROMONAS-HYDROPHILA CPHA GENE - MOLECULAR HETEROGENEITY AMONG CLASS-B METALLO-BETA-LACTAMASES [J].

MASSIDDA, O ;

ROSSOLINI, GM ;

SATTA, G .

JOURNAL OF BACTERIOLOGY, 1991, 173 (15) :4611-4617

[9] Characterization of SFO-1, a plasmid-mediated inducible class A β-lactamase from Enterobacter cloacae [J].

Matsumoto, Y ;

Inoue, M .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (02) :307-313

[10] Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites [J].

Nielsen, H ;

Engelbrecht, J ;

Brunak, S ;

vonHeijne, G .

PROTEIN ENGINEERING, 1997, 10 (01) :1-6