Simple preparation of chiral 1,3-dimethyl-2-iminoimidazolidines (monocyclic guanidines) and applications to asymmetric alkylative esterification

被引：60

作者：

Isobe, T

Fukuda, K

Ishikawa, T

机构：

[1] Shiratori Pharmaceut Co Ltd, Cent Res Lab, Narashino, Chiba 2750016, Japan

[2] Chiba Univ, Fac Pharmaceut Sci, Chiba 2638522, Japan

来源：

TETRAHEDRON-ASYMMETRY | 1998年 / 9卷 / 10期

关键词：

D O I：

10.1016/S0957-4166(98)00152-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

New chiral 1,3-dimethyl-2-iminoimidazolidines (monocyclic guanidines) were simply prepared by the action of primary amines on 2-chloro-1,3-dimethylimidazolinium chlorides, derived from the corresponding urea, in high yields. Modest asymmetric induction in alkylative esterification of benzoic acid with (1-bromoethyl)benzene was observed when the 1,3-dimethyl-4,5-diphenyl-2-[(1-phenyl-or 1-naphthyl)ethylimino]imidazolidines with all S (or R) configurations were used as bases. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：1729 / 1735

页数：7

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