Toll-like receptor-mediated NF-κB activation:: a phylogenetically conserved paradigm in innate immunity

被引:609
作者
Zhang, GL
Ghosh, S
机构
[1] Yale Univ, Sch Med, Howard Hughes Med Inst, Immunobiol Sect, New Haven, CT 06520 USA
[2] Yale Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA
关键词
D O I
10.1172/JCI11837
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
[No abstract available]
引用
收藏
页码:13 / 19
页数:7
相关论文
共 49 条
  • [1] The apoptotic signaling pathway activated by Toll-like receptor-2
    Aliprantis, AO
    Yang, RB
    Weiss, DS
    Godowski, P
    Zychlinsky, A
    [J]. EMBO JOURNAL, 2000, 19 (13) : 3325 - 3336
  • [2] Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2
    Aliprantis, AO
    Yang, RB
    Mark, MR
    Suggett, S
    Devaux, B
    Radolf, JD
    Klimpel, GR
    Godowski, P
    Zychlinsky, A
    [J]. SCIENCE, 1999, 285 (5428) : 736 - 739
  • [3] Toll signaling pathways in the innate immune response
    Anderson, KV
    [J]. CURRENT OPINION IN IMMUNOLOGY, 2000, 12 (01) : 13 - 19
  • [4] TLR4 mutations are associated with endotoxin hyporesponsiveness in humans
    Arbour, NC
    Lorenz, E
    Schutte, BC
    Zabner, J
    Kline, JN
    Jones, M
    Frees, K
    Watt, JL
    Schwartz, DA
    [J]. NATURE GENETICS, 2000, 25 (02) : 187 - +
  • [5] HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine
    Asea, A
    Kraeft, SK
    Kurt-Jones, EA
    Stevenson, MA
    Chen, LB
    Finberg, RW
    Koo, GC
    Calderwood, SK
    [J]. NATURE MEDICINE, 2000, 6 (04) : 435 - 442
  • [6] Signaling in plant-microbe interactions
    Baker, B
    Zambryski, P
    Staskawicz, B
    DineshKumar, SP
    [J]. SCIENCE, 1997, 276 (5313) : 726 - 733
  • [7] Control of apoptosis by Rel/NF-κB transcription factors
    Barkett, M
    Gilmore, TD
    [J]. ONCOGENE, 1999, 18 (49) : 6910 - 6924
  • [8] A conserved signaling pathway: The Drosophila Toll-Dorsal pathway
    Belvin, MP
    Anderson, KV
    [J]. ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1996, 12 : 393 - 416
  • [9] Tlr4: central component of the sole mammalian LPS sensor
    Beutler, B
    [J]. CURRENT OPINION IN IMMUNOLOGY, 2000, 12 (01) : 20 - 26
  • [10] Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors
    Brightbill, HD
    Libraty, DH
    Krutzik, SR
    Yang, RB
    Belisle, JT
    Bleharski, JR
    Maitland, M
    Norgard, MV
    Plevy, SE
    Smale, ST
    Brennan, PJ
    Bloom, BR
    Godowski, PJ
    Modlin, RL
    [J]. SCIENCE, 1999, 285 (5428) : 732 - 736