Snake venom C-type lectins as tools in platelet research

被引：13

作者：

Clemetson, KJ ^{[1
]}

Polgar, J ^{[1
]}

Clemetson, JM ^{[1
]}

机构：

[1] Univ Bern, Theodor Kocher Inst, CH-3012 Bern, Switzerland

来源：

PLATELETS | 1998年 / 9卷 / 3-4期

关键词：

D O I：

10.1080/09537109876636

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The snake C-type lectins are a major group of proteins present in venoms that fold to a structure with similarities to classic C-type lectins, The loop that would be involved in calcium and sugar binding is truncated and heterodimers are linked by a disulphide bond and by swapping loop domains between the subunits. Many of these C-type lectins interact with platelet receptors to inhibit or induce platelet activation. The use of these C-type lectins to investigate platelet function is discussed and illustrated with specific examples.

引用

页码：165 / 169

页数：5

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