NetAcet: prediction of N-terminal acetylation sites

被引：110

作者：

Kiemer, L ^{[1
]}

Bendtsen, JD ^{[1
]}

Blom, N ^{[1
]}

机构：

[1] Tech Univ Denmark, Ctr Biol Sequence Anal, Biocentrum DTU, DK-2800 Lyngby, Denmark

来源：

BIOINFORMATICS | 2005年 / 21卷 / 07期

关键词：

D O I：

10.1093/bioinformatics/bti130

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Summary: We present here a neural network based method for prediction of N-terminal acetylation-by far the most abundant post-translational modification in eukaryotes. The method was developed on a yeast dataset for N-acetyltransferase A (NatA) acetylation, which is the type of N-acetylation for which most examples are known and for which orthologs have been found in several eukaryotes. We obtain correlation coefficients close to 0.7 on yeast data and a sensitivity up to 74% on mammalian data, suggesting that the method is valid for eukaryotic NatA orthologs.

引用

页码：1269 / 1270

页数：2

共 13 条

[1]

Apweiler R, 2004, NUCLEIC ACIDS RES, V32, pD115, DOI [10.1093/nar/gkw1099, 10.1093/nar/gkh131]

[2] HOW MUCH SEQUENCE INFORMATION IS NEEDED FOR THE REGULATION OF AMINO-TERMINAL ACETYLATION OF EUKARYOTIC PROTEINS [J].

AUGEN, J ;

WOLD, F .

TRENDS IN BIOCHEMICAL SCIENCES, 1986, 11 (12) :494-497

[3] Cleavage site analysis in picornaviral polyproteins: Discovering cellular targets by neural networks [J].

Blom, N ;

Hansen, J ;

Blaas, D ;

Brunak, S .

PROTEIN SCIENCE, 1996, 5 (11) :2203-2216

[4]

Cover T. M., 2005, ELEM INF THEORY, DOI 10.1002/047174882X

[5] COMPARISON OF PREDICTED AND OBSERVED SECONDARY STRUCTURE OF T4 PHAGE LYSOZYME [J].

MATTHEWS, BW .

BIOCHIMICA ET BIOPHYSICA ACTA, 1975, 405 (02) :442-451

[6] Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites [J].

Nielsen, H ;

Engelbrecht, J ;

Brunak, S ;

vonHeijne, G .

PROTEIN ENGINEERING, 1997, 10 (01) :1-6

[7]

Perrot M, 1999, ELECTROPHORESIS, V20, P2280, DOI 10.1002/(SICI)1522-2683(19990801)20:11<2280::AID-ELPS2280>3.3.CO

[8]

2-H

[9] Nα-terminal acetylation of eukaryotic proteins [J].

Polevoda, B ;

Sherman, F .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (47) :36479-36482

[10] N-terminal acetyltransferases and sequence requirements for N-terminal acetylation of eukaryotic proteins [J].

Polevoda, B ;

Sherman, F .

JOURNAL OF MOLECULAR BIOLOGY, 2003, 325 (04) :595-622

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