Progression of coronary artery calcification and cardiac events in patients with chronic renal disease not receiving dialysis

被引：105

作者：

Russo, Domenico ^{[1
]}

Corrao, Salvatore ^{[2
]}

Battaglia, Yuri ^{[1
]}

Andreucci, Michele ^{[3
]}

Caiazza, Antonella ^{[1
]}

Carlomagno, Angelo ^{[4
]}

Lamberti, Monica ^{[5
]}

Pezone, Nicoletta ^{[1
]}

Pota, Andrea ^{[1
]}

Russo, Luigi ^{[1
]}

Sacco, Maurizio ^{[5
]}

Scognamiglio, Bernadette ^{[1
]}

机构：

[1] Univ Naples Federico II, Dept Nephrol, Naples, Italy

[2] Univ Palermo, Dipartimento Biomed Med Interna & Specialist, Palermo, Italy

[3] Univ Catanzaro, Dept Nephrol, Catanzaro, Italy

[4] Univ Naples Federico II, Dept Cardiol, Naples, Italy

[5] San Gennaro Hosp, Dept Radiol, Naples, Italy

来源：

KIDNEY INTERNATIONAL | 2011年 / 80卷 / 01期

关键词：

cardiovascular events; chronic kidney disease; coronary calcification; CHRONIC KIDNEY-DISEASE; NONTRADITIONAL RISK-FACTORS; VASCULAR CALCIFICATION; CULPRIT PLAQUE; MORTALITY; IMPACT; PATHOPHYSIOLOGY; ATHEROSCLEROSIS; INFLAMMATION; POPULATION;

D O I：

10.1038/ki.2011.69

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

We tested for the presence of coronary calcifications in patients with chronic renal disease not on dialysis and studied its progression in 181 consecutive non-dialyzed patients who were followed for a median of 745 days. Coronary calcifications (calcium score) were tallied in Agatston units by computed tomography, and the patients were stratified into two groups by their baseline calcium score (100 U or less and over 100 U). Survival was measured by baseline calcium score and its progression. Cardiac death and myocardial infarction occurred in 29 patients and were significantly more frequent in those patients with calcium scores over 100 U (hazard ratio of 4.11). With a calcium score of 100 U or less, the hazard ratio for cardiac events was 0.41 and 3.26 in patients with absent and accelerated progression, respectively. Thus, in non-dialyzed patients, the extent of coronary calcifications was associated to cardiac events, and progression was an independent predictive factor of cardiac events mainly in less calcified patients. Hence, assessment of coronary calcifications and progression might be useful for earlier management of risk factors and guiding decisions for prevention of cardiac events in this patient population.

引用

页码：112 / 118

页数：7

共 48 条

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