The influence of age on intestinal dipeptidyl peptidase IV (DPP IV/CD26), disaccharidases, and alkaline phosphatase enzyme activity in C57BL/6 mice

被引：28

作者：

Detel, Dijana ^{[1
]}

Baticic, Lara ^{[1
]}

Varljen, Jadranka ^{[1
]}

机构：

[1] Univ Rijeka, Sch Med, Dept Chem & Biochem, HR-51000 Rijeka, Croatia

来源：

EXPERIMENTAL AGING RESEARCH | 2008年 / 34卷 / 01期

关键词：

D O I：

10.1080/03610730701761957

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 [法学]; 0303 [社会学]; 100203 [老年医学];

摘要：

The objective of this study was to determine and describe the age-related changes in intestinal brush border membrane enzyme activities that occur in C57Bl/6 mice. Specifically, jejunal, duodenal, and ileal dipeptidyl peptidase IV/CD26, disaccharidase (lactase, sucrase, and maltase), and alkaline phosphatase activities were determined. A significant correlation between analyzed intestinal brush border membrane enzyme activities and animal age was found. Our study revealed that intestinal dipeptidyl peptidase IV/CD26, lactase, sucrase, maltase, and alkaline phosphatase activities decline significantly with age (p.05). Nevertheless, the horizontal (duodenum to ileum) enzyme activity patterns are not affected by age.

引用

页码：49 / 62

页数：14

共 29 条

[1]

AHNEN DJ, 1982, J BIOL CHEM, V257, P2129

[2]

ALKALINE-PHOSPHATASE ACTIVITY IN FRESH INTESTINAL-MUCOSA AND CULTURED MUCOSAL EXPLANTS [J].

ASHKENAZI, A ;

IDAR, D ;

MAIMON, M ;

HEGESH, E ;

FRANK, E ;

HAHN, T ;

WOLMAN, Y ;

LEVIN, S .

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 1984, 3 (02) :210-214

[3]

DIET FATTY-ACID COMPOSITION, AGE AND RAT JEJUNAL MICROVILLUS ENZYME-ACTIVITIES [J].

BERNARD, A ;

CASELLI, C ;

BLOND, JP ;

CARLIER, H .

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-PHYSIOLOGY, 1992, 101 (03) :607-612

[4]

BOWERS GN, 1975, CLIN CHEM, V21, P1988

[5]

BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3

[6]

Intestinal transport of monosaccharides and amino acids during postnatal development of mink [J].

Buddington, RK ;

Malo, C ;

Sangild, PT ;

Elnif, J .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2000, 279 (06) :R2287-R2296

[7]

Differences between duodenal and jejunal rat alkaline phosphatase [J].

Calhau, C ;

Martel, F ;

Hipólito-Reis, C ;

Azevedo, I .

CLINICAL BIOCHEMISTRY, 2000, 33 (07) :571-577

[8]

ASSAY OF INTESTINAL DISACCHARIDASES [J].

DAHLQVIST, A .

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 1984, 44 (02) :169-172

[9]

REGIONAL EXPRESSION OF EPITHELIAL DIPEPTIDYL PEPTIDASE-IV IN THE HUMAN INTESTINES [J].

DARMOUL, D ;

VOISIN, T ;

COUVINEAU, A ;

ROUYERFESSARD, C ;

SALOMON, R ;

WANG, YX ;

SWALLOW, DM ;

LABURTHE, M .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 203 (02) :1224-1229

[10]

REGULATION OF INTESTINAL NUTRIENT TRANSPORT IS IMPAIRED IN AGED MICE [J].

FERRARIS, RP ;

VINNAKOTA, RR .

JOURNAL OF NUTRITION, 1993, 123 (03) :502-511

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