Metastable states and folding free energy barriers

被引：37

作者：

Baker, D ^{[1
]}

机构：

[1] Univ Washington, Dept Biochem, Seattle, WA 98195 USA

来源：

NATURE STRUCTURAL BIOLOGY | 1998年 / 5卷 / 12期

关键词：

D O I：

10.1038/4130

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The demonstration that the native state of a long lived protease is less stable than a partially folded 'molten globule' like state shatters long standing preconceptions about protein folding.

引用

页码：1021 / 1024

页数：4

共 15 条

[1] PROTEASE PRO-REGION REQUIRED FOR FOLDING IS A POTENT INHIBITOR OF THE MATURE ENZYME [J].

BAKER, D ;

SILEN, JL ;

AGARD, DA .

PROTEINS-STRUCTURE FUNCTION AND GENETICS, 1992, 12 (04) :339-344

[2] A PROTEIN-FOLDING REACTION UNDER KINETIC CONTROL [J].

BAKER, D ;

SOHL, JL ;

AGARD, DA .

NATURE, 1992, 356 (6366) :263-265

[3] The role of pro regions in protein folding [J].

Baker, David ;

Shiau, Andrew K. ;

Agard, David A. .

CURRENT OPINION IN CELL BIOLOGY, 1993, 5 (06) :966-970

[4] ENERGETICS OF FOLDING SUBTILISIN BPN' [J].

BRYAN, P ;

ALEXANDER, P ;

STRAUSBERG, S ;

SCHWARZ, F ;

LAN, W ;

GILLILAND, G ;

GALLAGHER, DT .

BIOCHEMISTRY, 1992, 31 (21) :4937-4945

[5] A soluble domain of the membrane-anchoring chain of influenza virus hemagglutinin (HA(2)) folds in Escherichia coli into the low-pH-induced conformation [J].

Chen, J ;

Wharton, SA ;

Weissenhorn, W ;

Calder, LJ ;

Hughson, FM ;

Skehel, JJ ;

Wiley, DC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (26) :12205-12209

[6] THE PROSEGMENT-SUBTILISIN BPN COMPLEX - CRYSTAL-STRUCTURE OF A SPECIFIC FOLDASE [J].

GALLAGHER, T ;

GILLILAND, G ;

WANG, L ;

BRYAN, P .

STRUCTURE, 1995, 3 (09) :907-914

[7] 3-DIMENSIONAL STRUCTURE OF PORCINE PANCREATIC PROCARBOXYPEPTIDASE-A - A COMPARISON OF THE A-ZYMOGEN AND B-ZYMOGEN AND THEIR DETERMINANTS FOR INHIBITION AND ACTIVATION [J].

GUASCH, A ;

COLL, M ;

AVILES, FX ;

HUBER, R .

JOURNAL OF MOLECULAR BIOLOGY, 1992, 224 (01) :141-157

[8] The sequences of small proteins are not extensively optimized for rapid folding by natural selection [J].

Kim, DE ;

Gu, HD ;

Baker, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (09) :4982-4986

[9] PRO-PEPTIDE AS AN INTERMOLECULAR CHAPERONE - RENATURATION OF DENATURED SUBTILISIN-E WITH A SYNTHETIC PRO-PEPTIDE [J].

OHTA, Y ;

HOJO, H ;

AIMOTO, S ;

KOBAYASHI, T ;

ZHU, X ;

JORDAN, F ;

INOUYE, M .

MOLECULAR MICROBIOLOGY, 1991, 5 (06) :1507-1510

[10]

PETERS, 1998, BIOCHEMISTRY, V37, P12058

← 1 2 →