Genetic and antibody-induced glycoprotein VI deficiency equally protects mice from mechanically and FeCl3-induced thrombosis

被引:78
作者
Bender, M.
Hagedorn, I.
Nieswandt, B. [1 ]
机构
[1] Univ Wurzburg, Univ Hosp Wurzburg, D-97080 Wurzburg, Germany
关键词
COLLAGEN RECEPTOR; IN-VIVO; GAMMA-CHAIN; ASSOCIATION; ACTIVATION; MECHANISMS; PLATELETS; DEPLETION; GPVI;
D O I
10.1111/j.1538-7836.2011.04328.x
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
引用
收藏
页码:1423 / 1426
页数:4
相关论文
共 24 条
[1]
Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases [J].
Bender, Markus ;
Hofmann, Sebastian ;
Stegner, David ;
Chalaris, Athena ;
Boesl, Michael ;
Braun, Attila ;
Scheller, Juergen ;
Rose-John, Stefan ;
Nieswandt, Bernhard .
BLOOD, 2010, 116 (17) :3347-3355
[2]
A ride with ferric chloride [J].
Brill, A. .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2011, 9 (04) :776-778
[3]
Thrombin-initiated platelet activation in vivo is vWF independent during thrombus formation in a laser injury model [J].
Dubois, Christophe ;
Panicot-Dubois, Laurence ;
Gainor, Justin F. ;
Furie, Barbara C. ;
Furie, Bruce .
JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (04) :953-960
[4]
Glycoprotein VI-dependent and -independent pathways of thrombus formation in vivo [J].
Dubois, Christophe ;
Panicot-Dubois, Laurence ;
Merrill-Skoloff, Glenn ;
Furie, Bruce ;
Furie, Barbara C. .
BLOOD, 2006, 107 (10) :3902-3906
[5]
Mechanisms underlying FeCl3-induced arterial thrombosis [J].
Eckly, A. ;
Hechler, B. ;
Freund, M. ;
Zerr, M. ;
Cazenave, J. -P. ;
Lanza, F. ;
Mangin, P. H. ;
Gachet, C. .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2011, 9 (04) :779-789
[6]
Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor gamma-chain [J].
Gibbins, JM ;
Okuma, M ;
Farndale, R ;
Barnes, M ;
Watson, SP .
FEBS LETTERS, 1997, 413 (02) :255-259
[7]
Anti-glycoprotein VI treatment severely compromises hemostasis in mice with reduced α2β1 levels or concomitant aspirin therapy [J].
Grüner, S ;
Prostredna, M ;
Aktas, B ;
Moers, A ;
Schulte, V ;
Krieg, T ;
Offermanns, S ;
Eckes, B ;
Nieswandt, B .
CIRCULATION, 2004, 110 (18) :2946-2951
[8]
Arterial thrombosis: relevance of a model with two levels of severity assessed by histologic, ultrastructural and functional characterization [J].
Hechler, B. ;
Nonne, C. ;
Eckly, A. ;
Magnenat, S. ;
Rinckel, J. -Y. ;
Denis, C. V. ;
Freund, M. ;
Cazenave, J-P. ;
Lanza, F. ;
Gachet, C. .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2010, 8 (01) :173-184
[9]
Laminin stimulates spreading of platelets through integrin α6β1-dependent activation of GPVI [J].
Inoue, O ;
Suzuki-Inoue, K ;
McCarty, OJT ;
Moroi, M ;
Ruggeri, ZM ;
Kunicki, TJ ;
Ozaki, Y ;
Watson, SP .
BLOOD, 2006, 107 (04) :1405-1412
[10]
Critical role of FcR γ-chain, LAT, PLCγ2 and thrombin in arteriolar thrombus formation upon mild, laser-induced endothelial injury in vivo [J].
Kalia, Neena ;
Auger, Jocelyn M. ;
Atkinson, Ben ;
Watson, Steve P. .
MICROCIRCULATION, 2008, 15 (04) :325-335