Lack of Protection Against Ebola Virus from Chloroquine in Mice and Hamsters

被引：44

作者：

Falzarano, Darryl ^{[1
]}

Safronetz, David ^{[1
]}

Prescott, Joseph ^{[1
]}

Marzi, Andrea ^{[1
]}

Feldmann, Friederike ^{[1
]}

Feldmann, Heinz ^{[1
]}

机构：

[1] NIAID, Hamilton, MT USA

来源：

EMERGING INFECTIOUS DISEASES | 2015年 / 21卷 / 06期

基金：

美国国家卫生研究院;

关键词：

HEMORRHAGIC-FEVER; CORONAVIRUS; INFECTION; DISEASE; MODEL;

D O I：

10.3201/eid2106.150176

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The antimalarial drug chloroquine has been suggested as a treatment for Ebola virus infection. Chloroquine inhibited virus replication in vitro, but only at cytotoxic concentrations. In mouse and hamster models, treatment did not improve survival. Chloroquine is not a promising treatment for Ebola. Efforts should be directed toward other drug classes.

引用

收藏

页码：1065 / 1067

页数：3

相关论文

共 15 条

[1]

[Anonymous], B WHO

[2] Potential and Emerging Treatment Options for Ebola Virus Disease [J].

Bishop, Bryan M. .

ANNALS OF PHARMACOTHERAPY, 2015, 49 (02) :196-206

[3] A mouse model for evaluation of prophylaxis and therapy of Ebola hemorrhagic fever [J].

Bray, M ;

Davis, K ;

Geisbert, T ;

Schmaljohn, C ;

Huggins, J .

JOURNAL OF INFECTIOUS DISEASES, 1998, 178 (03) :651-661

[4]

Burke J, 1978, B WORLD HEALTH ORGAN, V56, P271

[5] Ebola virus (EBOV) infection: Therapeutic strategies [J].

De Clercq, Erik .

BIOCHEMICAL PHARMACOLOGY, 2015, 93 (01) :1-10

[6] Chikungunya Disease and Chloroquine Treatment [J].

Delogu, Ilenia ;

de lamballerie, Xavier .

JOURNAL OF MEDICAL VIROLOGY, 2011, 83 (06) :1058-1059

[7] A Syrian Golden Hamster Model Recapitulating Ebola Hemorrhagic Fever [J].

Ebihara, Hideki ;

Zivcec, Marko ;

Gardner, Donald ;

Falzarano, Darryl ;

LaCasse, Rachel ;

Rosenke, Rebecca ;

Long, Dan ;

Haddock, Elaine ;

Fischer, Elizabeth ;

Kawaoka, Yoshihiro ;

Feldmann, Heinz .

JOURNAL OF INFECTIOUS DISEASES, 2013, 207 (02) :306-318

[8] In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine [J].

Keyaerts, E ;

Vijgen, L ;

Maes, P ;

Neyts, J ;

Van Ranst, M .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 323 (01) :264-268

[9] Antiviral Activity of Chloroquine against Human Coronavirus OC43 Infection in Newborn Mice [J].

Keyaerts, Els ;

Li, Sandra ;

Vijgen, Leen ;

Rysman, Evelien ;

Verbeeck, Jannick ;

Van Ranst, Marc ;

Maes, Piet .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2009, 53 (08) :3416-3421

[10] A Systematic Screen of FDA-Approved Drugs for Inhibitors of Biological Threat Agents [J].

Madrid, Peter B. ;

Chopra, Sidharth ;

Manger, Ian D. ;

Gilfillan, Lynne ;

Keepers, Tiffany R. ;

Shurtleff, Amy C. ;

Green, Carol E. ;

Iyer, Lalitha V. ;

Dilks, Holli Hutcheson ;

Davey, Robert A. ;

Kolokoltsov, Andrey A. ;

Carrion, Ricardo, Jr. ;

Patterson, Jean L. ;

Bavari, Sina ;

Panchal, Rekha G. ;

Warren, Travis K. ;

Wells, Jay B. ;

Moos, Walter H. ;

Burke, RaeLyn L. ;

Tanga, Mary J. .

PLOS ONE, 2013, 8 (04)