Molecular mechanism of PPAR in the regulation of age-related inflammation

被引：103

作者：

Chung, Jae Heun ^{[1
]}

Seo, Amold Y. ^{[2
]}

Chung, Sang Woon ^{[1
]}

Kim, Mi Kyung ^{[3
]}

Leeuwenburgh, Christiaan ^{[2
]}

Yu, Byung Pal ^{[4
]}

Chung, Hae Young ^{[1
,2
]}

机构：

[1] Pusan Natl Univ, Coll Pharm, Dept Pharm, Pusan 609735, South Korea

[2] Univ Florida, Coll Med, Inst Aging, Dept Aging & Geriatr,Biochem Aging Lab, Gainesville, FL 32610 USA

[3] Pusan Natl Univ, Longev Life Sci & Technol Inst, Pusan 609735, South Korea

[4] Univ Texas Hlth Sci Ctr San Antonio, Dept Physiol, San Antonio, TX 78229 USA

来源：

AGEING RESEARCH REVIEWS | 2008年 / 7卷 / 02期

关键词：

PPARs; aging; inflammation; inflammatory diseases;

D O I：

10.1016/j.arr.2008.01.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Evidence from many recent studies has linked uncontrolled inflammatory processes to aging and aging-related diseases. Decreased a nuclear receptor subfamily of transcription factors, peroxisome proliferator-activated receptors (PPARs) activity is closely associated with increased levels of inflammatory mediators during the aging process. The anti-inflammatory action of PPARs is substantiated by both in vitro and in vivo studies that signify the importance of PPARs as major players in the pathogenesis of many inflammatory diseases. In this review, we highlight the molecular mechanisms and roles of PPAR alpha, gamma in regulation of agerelated inflammation. By understanding these current findings of PPARs, we open up the possibility of developing new therapeutic agents that modulate these nuclear receptors to control various inflammatory diseases such as atherosclerosis, vascular diseases, Alzheimer's disease, and cancer. (c) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：126 / 136

页数：11

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