Homeostatic defects in interleukin 18-deficient mice contribute to protection against the lethal effects of endotoxin

被引:17
作者
Andrews, Daniel M. [1 ]
Chow, Melvyn T. [1 ]
Ma, Yuting [2 ,3 ]
Cotterell, Claire L. [1 ]
Watt, Sally V. [1 ]
Anthony, Desiree A. [1 ]
Akira, Shizuo [4 ]
Iwakura, Yoichiro [5 ,6 ]
Trapani, Joseph A. [1 ]
Zitvogel, Laurence [2 ,3 ,7 ,8 ]
Smyth, Mark J. [1 ]
机构
[1] Peter MacCallum Canc Ctr, Trescowthick Labs, Canc Immunol Program, Melbourne, Vic 3002, Australia
[2] Inst Gustave Roussy, Villejuif, France
[3] INSERM, U805, Villejuif, France
[4] Osaka Univ, WPI Immunol Frontier Res Ctr, Host Def Lab, Osaka, Japan
[5] Univ Tokyo, Inst Med Sci, Ctr Expt Med & Syst Biol, Tokyo, Japan
[6] Japan Sci & Technol Agcy, CREST, Saitama, Japan
[7] Ctr Clin Invest Biotherapies Canc CICBT 507, Villejuif, France
[8] Univ Paris 11, Fac Med, Le Kremlin Bicetre, France
基金
澳大利亚国家健康与医学研究理事会;
关键词
innate immunity; natural killer; gamma delta T cell; cytokines; cross-talk; GAMMA-INDUCING FACTOR; NATURAL-KILLER-CELLS; T-HELPER TYPE-1; IFN-GAMMA; NK CELLS; DENDRITIC CELLS; POSTTRANSCRIPTIONAL CONTROL; IL-18-DEFICIENT MICE; IL-18; SHOCK;
D O I
10.1038/icb.2010.168
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Toll-like receptor-4-lipopolysaccharide (LPS)-mediated inflammation is used to delineate signals involved in cross-talk between antigen-presenting cells (APCs) and lymphocytes such as natural killer (NK) cells. Following APC stimulation and cytokine release, NK cells produce interferon (IFN)-gamma. High levels of LPS induce endotoxicosis, a systemic inflammatory disease in which IFN-gamma causes significant morbidity and mortality. Several studies have highlighted the role of interleukin (IL)-18, IL-1 beta, IL-17A and IFN-gamma in the development of endotoxicosis, but whether these cytokines interact with each other is yet to be determined. Our data demonstrate that IL-18 and IL-17A have important roles in NK cell IFN-gamma production during endotoxicosis. Importantly, we provide the first evidence that IL-18 also has a role in IL-17A production by T-cell receptor (TCR)-delta cells. Furthermore, we demonstrate that IL-18-deficient mice have a defect in gamma delta T-cell homeostasis and IL-1 beta production, both of which can contribute to the development of disease through induction of IL-17A. These results reveal novel requirements for IL-18 in innate immune cell homeostasis and activation, demonstrating that the role of IL-18 in innate immunity occurs at a level other than activation. Immunology and Cell Biology (2011) 89, 739-746; doi:10.1038/icb.2010.168; published online 25 January 2011
引用
收藏
页码:739 / 746
页数:8
相关论文
共 49 条
[1]   Toll-like receptor signalling [J].
Akira, S ;
Takeda, K .
NATURE REVIEWS IMMUNOLOGY, 2004, 4 (07) :499-511
[2]   Interaction between conventional dendritic cells and natural killer cells is integral to the activation of effective antiviral immunity [J].
Andoniou, CE ;
van Dommelen, SLH ;
Voigt, V ;
Andrews, DM ;
Brizard, G ;
Asselin-Paturel, C ;
Delale, T ;
Stacey, KJ ;
Trinchieri, G ;
Degli-Esposti, MA .
NATURE IMMUNOLOGY, 2005, 6 (10) :1011-1019
[3]   A Role for Granzyme M in TLR4-Driven Inflammation and Endotoxicosis [J].
Anthony, Desiree A. ;
Andrews, Daniel M. ;
Chow, Melvyn ;
Watt, Sally V. ;
House, Colin ;
Akira, Shizuo ;
Bird, Phillip I. ;
Trapani, Joseph A. ;
Smyth, Mark J. .
JOURNAL OF IMMUNOLOGY, 2010, 185 (03) :1794-1803
[4]   Functional caspase-1 is required for langerhans cell migration and optimal contact sensitization in mice [J].
Antonopoulos, H ;
Cumberbatch, M ;
Dearman, RJ ;
Daniel, RJ ;
Kimber, I ;
Groves, RW .
JOURNAL OF IMMUNOLOGY, 2001, 166 (06) :3672-3677
[5]   IL-1, IL-18, and IL-33 families of cytokines [J].
Arend, William P. ;
Palmer, Gaby ;
Gabay, Cem .
IMMUNOLOGICAL REVIEWS, 2008, 223 :20-38
[6]   Human interferon-γ mRNA autoregulates its translation through a pseudoknot that activates the interferon-inducible protein kinase PKR [J].
Ben-Asouli, Y ;
Banai, Y ;
Pel-Or, Y ;
Shir, A ;
Kaempfer, R .
CELL, 2002, 108 (02) :221-232
[7]   INTERFERON-GAMMA RECEPTOR-DEFICIENT MICE ARE RESISTANT TO ENDOTOXIC-SHOCK [J].
CAR, BD ;
ENG, VM ;
SCHNYDER, B ;
OZMEN, L ;
HUANG, S ;
GALLAY, P ;
HEUMANN, D ;
AGUET, M ;
RYFFEL, B .
JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 179 (05) :1437-1444
[8]   Cutting edge:: Priming of NK cells by IL-18 [J].
Chaix, Julie ;
Tessmer, Marlowe S. ;
Hoebe, Kasper ;
Fuseri, Nicolas ;
Ryffel, Bernhard ;
Dalod, Marc ;
Alexopoulou, Lena ;
Beutler, Bruce ;
Brossay, Laurent ;
Vivier, Eric ;
Walzer, Thierry .
JOURNAL OF IMMUNOLOGY, 2008, 181 (03) :1627-1631
[9]   DNAM-1/CD155 Interactions Promote Cytokine and NK Cell-Mediated Suppression of Poorly Immunogenic Melanoma Metastases [J].
Chan, Christopher J. ;
Andrews, Daniel M. ;
McLaughlin, Nicole M. ;
Yagita, Hideo ;
Gilfillan, Susan ;
Colonna, Marco ;
Smyth, Mark J. .
JOURNAL OF IMMUNOLOGY, 2010, 184 (02) :902-911
[10]   Developmental and functional defects of thymic and epidermal Vγ3 cells in IL-15-deficient and IFN regulatory factor-1-deficient mice [J].
De Creus, A ;
Van Beneden, K ;
Stevenaert, F ;
Debacker, V ;
Plum, J ;
Leclercq, G .
JOURNAL OF IMMUNOLOGY, 2002, 168 (12) :6486-6493