Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies

被引：702

作者：

Lipson, Doron ^{[1
]}

Capelletti, Marzia ^{[2
]}

Yelensky, Roman ^{[1
]}

Otto, Geoff ^{[1
]}

Parker, Alex ^{[1
]}

Jarosz, Mirna ^{[1
]}

Curran, John A. ^{[1
]}

Balasubramanian, Sohail ^{[1
]}

Bloom, Troy ^{[1
]}

Brennan, Kristina W. ^{[1
]}

Donahue, Amy ^{[1
]}

Downing, Sean R. ^{[1
]}

Frampton, Garrett M. ^{[1
]}

Garcia, Lazaro ^{[1
]}

Juhn, Frank ^{[1
]}

Mitchell, Kathy C. ^{[1
]}

White, Emily ^{[1
]}

White, Jared ^{[1
]}

Zwirko, Zac ^{[1
]}

Peretz, Tamar ^{[3
]}

Nechushtan, Hovav ^{[3
]}

Soussan-Gutman, Lior ^{[4
]}

Kim, Jhingook ^{[5
]}

Sasaki, Hidefumi ^{[6
]}

Kim, Hyeong Ryul ^{[7
]}

Park, Seung-il ^{[7
]}

Ercan, Dalia ^{[2
]}

Sheehan, Christine E. ^{[8
]}

Ross, Jeffrey S. ^{[1
,8
]}

Cronin, Maureen T. ^{[1
]}

Jaenne, Pasi A. ^{[2
]}

Stephens, Philip J. ^{[1
]}

机构：

[1] Fdn Med, Cambridge, MA USA

[2] Dana Farber Canc Inst, Lowe Ctr Thorac Oncol, Boston, MA 02115 USA

[3] Hadassah Hebrew Univ Med Ctr, Sharett Inst Oncol, Jerusalem, Israel

[4] Oncotest Teva Pharmaceut Ind, Petah Tiqwa, Israel

[5] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Thorac Surg, Seoul, South Korea

[6] Nagoya City Univ, Dept Oncol Immunol & Surg 2, Grad Sch Med Sci, Nagoya, Aichi, Japan

[7] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Thorac Surg, Seoul, South Korea

[8] Albany Med Ctr, Dept Pathol, Albany, NY USA

来源：

NATURE MEDICINE | 2012年 / 18卷 / 03期

基金：

日本学术振兴会;

关键词：

MUTATIONS; SENSITIVITY; CARCINOMAS; ACTIVATION; INHIBITOR; GEFITINIB; ERLOTINIB; CETUXIMAB; PATHWAYS; TUMORS;

D O I：

10.1038/nm.2673

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Applying a next-generation sequencing assay targeting 145 cancer-relevant genes in 40 colorectal cancer and 24 non-small cell lung cancer formalin-fixed paraffin-embedded tissue specimens identified at least one clinically relevant genomic alteration in 59% of the samples and revealed two gene fusions, C2orf44-ALK in a colorectal cancer sample and KIF5B-RET in a lung adenocarcinoma. Further screening of 561 lung adenocarcinomas identified 11 additional tumors with KIF5B-RET gene fusions (2.0%; 95% CI 0.8-3.1%). Cells expressing oncogenic KIF5B-RET are sensitive to multi-kinase inhibitors that inhibit RET.

引用

页码：382 / 384

页数：3

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