Marine natural product libraries for high-throughput screening and rapid drug discovery

被引：93

作者：

Bugni, Tim S. ^{[1
]}

Richards, Burt ^{[2
]}

Bhoite, Leen ^{[2
]}

Cimbora, Daniel ^{[2
]}

Harper, Mary Kay ^{[1
]}

Ireland, Chris M. ^{[1
]}

机构：

[1] Univ Utah, Dept Med Chem, Salt Lake City, UT 84112 USA

[2] Myriad Pharmaceut Inc, Salt Lake City, UT 84108 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 06期

关键词：

D O I：

10.1021/np800184g

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

There is a need for diverse molecular libraries for phenotype-selective and high-throughput screening. To make marine natural products (MNPs) more amenable to newer screening paradigms and shorten discovery time lines, we have created an MNP library characterized online using MS. To test the potential of the library, we screened a subset of the library in a phenotype-selective screen to identify compounds that inhibited the growth of BRCA2-deficient cells.

引用

页码：1095 / 1098

页数：4

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