Interpretation and use of FRAX in clinical practice

被引：424

作者：

Kanis, J. A. ^{[1
]}

Hans, D. ^{[2
]}

Cooper, C. ^{[3
,4
]}

Baim, S. ^{[5
]}

Bilezikian, J. P. ^{[6
]}

Binkley, N. ^{[7
]}

Cauley, J. A. ^{[8
]}

Compston, J. E. ^{[9
]}

Dawson-Hughes, B. ^{[10
]}

El-Hajj Fuleihan, Ghada ^{[11
]}

Johansson, H. ^{[12
]}

Leslie, W. D. ^{[13
]}

Lewiecki, E. M. ^{[14
]}

Luckey, M. ^{[15
]}

Oden, A. ^{[12
]}

Papapoulos, S. E. ^{[16
]}

Poiana, C. ^{[17
]}

Rizzoli, R. ^{[18
,19
]}

Wahl, D. A. ^{[20
]}

McCloskey, E. V. ^{[21
]}

机构：

[1] Univ Sheffield, Sch Med, WHO Collaborating Ctr Metab Bone Dis, Sheffield S10 2RX, S Yorkshire, England

[2] Univ Lausanne Hosp, Ctr Bone Dis, Bone & Joint Dept, Lausanne, Switzerland

[3] Univ Southampton, MRC Lifecourse Epidemiol Unit, Southampton, Hants, England

[4] Univ Oxford, NIHR Musculoskeletal Biomed Res Unit, Inst Musculoskeletal Sci, Oxford, England

[5] Univ Miami, Div Endocrinol, Miller Sch Med, Coral Gables, FL 33124 USA

[6] Columbia Univ Coll Phys & Surg, New York, NY 10032 USA

[7] Univ Wisconsin, Osteoporosis Clin Res Program, Madison, WI USA

[8] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburg, CA USA

[9] Univ Cambridge, Addenbrookes Hosp, Dept Med, Cambridge CB2 2QQ, England

[10] Tufts Univ, Jean Mayer US Dept Agr, Human Nutr Res Ctr Aging, Boston, MA 02111 USA

[11] Amer Univ Beirut, WHO Collaborating Ctr Metab Bone Disorders, Beirut, Lebanon

[12] Univ Gothenburg, Ctr Bone Res, Sahlgrenska Acad, Inst Med, Gothenburg, Sweden

[13] Univ Manitoba, Winnipeg, MB, Canada

[14] Univ New Mexico, Sch Med, New Mexico Clin Res & Osteoporosis Ctr, Albuquerque, NM 87131 USA

[15] St Barnabas Osteoporosis & Metab Bone Dis Ctr, Livingston, NJ USA

[16] Leiden Univ, Med Ctr, Dept Endocrinol & Metab Dis, Leiden, Netherlands

[17] Carol Davila Univ Med & Pharm, Dept Endocrinol, Bucharest, Romania

[18] Univ Hosp Geneva, Div Bone Dis, Dept Rehabil & Geriatr, Geneva, Switzerland

[19] Fac Med, Geneva, Switzerland

[20] Int Osteoporosis Fdn, Nyon, Switzerland

[21] Univ Sheffield, Acad Unit Bone Metab, Sheffield, S Yorkshire, England

来源：

OSTEOPOROSIS INTERNATIONAL | 2011年 / 22卷 / 09期

关键词：

Bone mineral density; Clinical risk factors; Fracture probability; Risk assessment; FRACTURE RISK-ASSESSMENT; BONE-MINERAL DENSITY; HIP FRACTURE; OSTEOPOROTIC FRACTURES; BIOCHEMICAL MARKERS; VERTEBRAL FRACTURE; ASSESSMENT TOOL; INHALED CORTICOSTEROIDS; ORAL CORTICOSTEROIDS; MULTIPLE SITES;

D O I：

10.1007/s00198-011-1713-z

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The introduction of the WHO FRAXA (R) algorithms has facilitated the assessment of fracture risk on the basis of fracture probability. Its use in fracture risk prediction has strengths, but also limitations of which the clinician should be aware and are the focus of this review Introduction The International Osteoporosis Foundation (IOF) and the International Society for Clinical Densitometry (ISCD) appointed a joint Task Force to develop resource documents in order to make recommendations on how to improve FRAX and better inform clinicians who use FRAX. The Task Force met in November 2010 for 3 days to discuss these topics which form the focus of this review. Methods This study reviews the resource documents and joint position statements of ISCD and IOF. Results Details on the clinical risk factors currently used in FRAX are provided, and the reasons for the exclusion of others are provided. Recommendations are made for the development of surrogate models where country-specific FRAX models are not available. Conclusions The wish list of clinicians for the modulation of FRAX is large, but in many instances, these wishes cannot presently be fulfilled; however, an explanation and understanding of the reasons may be helpful in translating the information provided by FRAX into clinical practice.

引用

页码：2395 / 2411

页数：17

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