Activation of the haemostatic system in children with juvenile rheumatoid arthritis correlates with disease activity

被引:24
作者
Gallistl, S
Mangge, H
Neuwirth, G
Muntean, W
机构
[1] Graz Univ, Klin Kinder & Jugendheilkunde, Dept Paediat, A-8036 Graz, Austria
[2] Graz Univ, Ludwig Boltzmann Inst Paediat Haemostasis & Throm, A-8036 Graz, Austria
关键词
juvenile rheumatoid arthritis; postinfectious arthropathies; coagulation; fibrinolysis;
D O I
10.1016/S0049-3848(98)00145-5
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Twenty-four children with juvenile rheumatoid arthritis (JRA) and 10 children with postinfectious arthropathies were investigated for markers of blood coagulation and fibrinolytic activity: Prothrombin fragment 1+2 (F1+2), thrombin-antithrombin complex (TAT), and D-Dimer were measured using solid phase enzyme linked immunosorbent assays (ELISA). Results were compared with clinical and conventional laboratory signs of disease activity. F1+2, TAT, D-Dimer, and fibrinogen were significantly elevated in children with JRA as compared with healthy children and children with postinfectious arthropathies. F1+2, TAT, and D-Dimer correlated significantly with disease activity, assessed by determination of the joint index score and C-reactive protein (CRP). The study demonstrates a subclinical activation of the haemostatic system in children with JRA correlating with disease activity, which might be caused by the action of several immunomediators on cells (monocytes, endothelial cells) playing a role in the regulation of blood coagulation activity. (C) 1998 Elsevier Science Ltd.
引用
收藏
页码:267 / 272
页数:6
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