Expression of bcl-6 and CD10 protein is associated with longer overall survival and time to treatment failure in follicular lymphoma

被引:42
作者
Bilalovic, N
Blystad, AK
Golouh, R
Nesland, JM
Selak, I
Trinh, D
Torlakovic, E [1 ]
机构
[1] Univ Oslo, Norwegian Radium Hosp, Dept Pathol, N-0310 Oslo, Norway
[2] Univ Hosp Sarajevo, Dept Pathol, Sarajevo, Bosnia & Herceg
[3] Univ Oslo, Norwegian Radium Hosp, Dept Oncol, Oslo, Norway
[4] Inst Oncol, Dept Pathol, Ljubljana, Slovenia
关键词
follicular lymphoma; bcl-6; CD10; overall survival; prognostic factors;
D O I
10.1309/TNKL7GDC66R9WPV5
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Follicular lymphomas (FLs) are a heterogeneous group of tumors, but prognostic factors are evaluated insufficiently in this common hematologic neoplasm. While bcl-6 and CD10 are expressed characteristically in FLs, their significance for biologic behavior of FL has not been studied previously. Samples from 73 patients with FL and clinical follow-up from 7 to 231 months were evaluated by immunohistochemical analysis. Patients with high levels of bcl-6 expression had favorable overall survival (OS) (P = .003), disease-specific survival (DSS) (P = .033), and time to treatment failure (P = .003) compared with patients with low levels of bcl-6 expression. Multivariate analysis showed that the results for OS, DSS, and time to treatment failure were independent of the international prognostic index. Patients with CD10+ FLs also had longer OS (P =. 001), DSS (P = .007), and time to treatment failure (P = .004), and grade I FL was associated with better OS (P =. 01) and a statistical trend for longer DSS (P = .05) and time to treatment failure (P = .05), but these results were not independent of bcl-6 expression or the international prognostic index in multivariate analysis.
引用
收藏
页码:34 / 42
页数:9
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