Reverse phase protein microarrays quantify and validate the bioenergetic signature as biomarker in colorectal cancer

被引：26

作者：

Aldea, M. ^{[1
,2
]}

Clofent, J. ^{[3
]}

Nunez de Arenas, C. ^{[2
]}

Chamorro, M. ^{[1
]}

Velasco, M. ^{[1
]}

Berrendero, J. R. ^{[5
]}

Navarro, C. ^{[4
]}

Cuezva, J. M. ^{[1
,2
]}

机构：

[1] Univ Autonoma Madrid, Ctr Biol Mol Severo Ochoa, CSIC, Dept Biol Mol, E-28049 Madrid, Spain

[2] Univ Autonoma Madrid, Hosp 12 Octubre, Inst Invest, E-28049 Madrid, Spain

[3] Hosp Univ Vigo, Serv Aparato Digestivo, Vigo 36200, Spain

[4] Hosp Univ Vigo, Dept Patol & Neuropatol, Vigo 36200, Spain

[5] Univ Autonoma Madrid, Dept Matemat, E-28049 Madrid, Spain

来源：

CANCER LETTERS | 2011年 / 311卷 / 02期

关键词：

ATP synthase; Energy metabolism; Glycolysis; Mitochondria; Predictive markers; Prognostic markers; BETA-F1-ATPASE MESSENGER-RNA; PYRUVATE-KINASE; DISEASE PROGRESSION; CELL-DEATH; M2; METABOLISM; EXPRESSION; SURVIVAL; 5-FLUOROURACIL; TRANSLATION;

D O I：

10.1016/j.canlet.2011.07.022

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

A reverse phase protein microarray approach has been applied to quantify proteins of energy metabolism in normal and tumor biopsies of colorectal cancer (CRC) patients. The metabolic proteome of CRC specimens revealed a profound shift towards and enhanced glycolytic phenotype and concurrent mitochondrial alteration. The metabolic signature discriminated CRC patients with highly significant differences in overall and disease-free prognosis. The quantification of the bioenergetic signature of the tumor offers a relevant biomarker of CRC that could contribute in the handling of these patients. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：210 / 218

页数：9

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