学术探索
学术期刊
新闻热点
数据分析
智能评审

Neuro-ophthalmology of mitochondrial diseases

被引：21
作者：
Biousse, V
Newman, NJ
机构：
[1] Emory Univ, Sch Med, Dept Ophthalmol, Atlanta, GA 30322 USA
[2] Emory Univ, Sch Med, Dept Neurol, Atlanta, GA 30322 USA
[3] Emory Univ, Sch Med, Dept Neurol Surg, Atlanta, GA 30322 USA
来源：
SEMINARS IN NEUROLOGY | 2001年 / 21卷 / 03期
关键词：
mitochondrial disease; optic neuropathy; Leber's hereditary optic neuropathy; ophthalmoplegia; CPEO; MELAS; pigmentary retinopathy; encephalopathy; homonymous hemianopia; cortical blindness;
D O I：
10.1055/s-2001-17945
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The afferent and efferent visual pathways within the central nervous system are frequently involved in mitochondrial diseases. Neuro-ophthalmic signs figure prominently and may be the presenting or even sole manifestation of these disorders. The four most common neuro-ophthalmic abnormalities seen in mitochondrial disorders are bilateral optic neuropathy, ophthalmoplegia with ptosis, pigmentary retinopathy, and retrochiasmal visual loss.
引用
收藏
页码：275 / 291
页数：17
相关论文
共 148 条
[1]   DEFECTIVE BRAIN AND MUSCLE ENERGY-METABOLISM SHOWN BY IN-VIVO P-31 MAGNETIC-RESONANCE SPECTROSCOPY IN NONAFFECTED CARRIERS OF 11778-MTDNA MUTATION [J].
BARBIROLI, B ;
MONTAGNA, P ;
CORTELLI, P ;
IOTTI, S ;
LODI, R ;
BARBONI, P ;
MONARI, L ;
LUGARESI, E ;
FRASSINETI, C ;
ZANIOL, P .
NEUROLOGY, 1995, 45 (07) :1364-1369
[2]   LUMPING OR SPLITTING - OPHTHALMOPLEGIA-PLUS OR KEARNS-SAYRE SYNDROME [J].
BERENBERG, RA ;
PELLOCK, JM ;
DIMAURO, S ;
SCHOTLAND, DL ;
BONILLA, E ;
EASTWOOD, A ;
HAYS, A ;
VICALE, CT ;
BEHRENS, M ;
CHUTORIAN, A ;
ROWLAND, LP .
ANNALS OF NEUROLOGY, 1977, 1 (01) :37-54
[3]   Leber's hereditary optic neuropathy: clinical and molecular genetic findings in a patient with a new mutation in the ND6 gene [J].
Besch, D ;
Leo-Kottler, B ;
Zrenner, E ;
Wissinger, B .
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 1999, 237 (09) :745-752
[4]  
Bhatti MT, 1999, J NEURO-OPHTHALMOL, V19, P28
[5]   Multiple mitochondrial DNA deletions associated with autosomal recessive ophthalmoplegia and severe cardiomyopathy [J].
Bohlega, S ;
Tanji, K ;
Santorelli, FM ;
Hirano, M ;
alJishi, A ;
DiMauro, S .
NEUROLOGY, 1996, 46 (05) :1329-1334
[6]  
Bremner FD, 1999, INVEST OPHTH VIS SCI, V40, P2528
[7]  
BROWN MD, 1994, CLIN NEUROSCI, V2, P138
[8]   The enigmatic relationship between mitochondrial dysfunction and Leber's hereditary optic neuropathy [J].
Brown, MD .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 1999, 165 (01) :1-5
[9]  
Brown MD, 1997, AM J HUM GENET, V60, P381
[10]   LEBER HEREDITARY OPTIC NEUROPATHY - A MODEL FOR MITOCHONDRIAL NEURODEGENERATIVE DISEASES [J].
BROWN, MD ;
VOLJAVEC, AS ;
LOTT, MT ;
MACDONALD, I ;
WALLACE, DC .
FASEB JOURNAL, 1992, 6 (10) :2791-2799
12345678910