A new VKORC1 allelic variant (p.Trp59Arg) in a patient with partial resistance to acenocoumarol and phenprocoumon

被引:23
作者
Wilms, E. B. [1 ]
Touw, D. J. [1 ]
Conemans, J. M. H. [2 ]
Veldkamp, R. [3 ]
Hermans, M. [2 ]
机构
[1] Cent Hosp Pharm, NL-2547 EX The Hague, Netherlands
[2] Jeroen Bosch Hosp, Lab Mol Diagnost, Shertogenbosch, Netherlands
[3] Med Ctr Haaglanden, Dept Cardiol, The Hague, Netherlands
关键词
D O I
10.1111/j.1538-7836.2008.02975.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页码:1224 / 1226
页数:4
相关论文
共 15 条
  • [1] A vitamin K epoxide reductase complex subunit-1 (VKORC1) mutation in a patient with vitamin K antagonist resistance
    Bodin, L
    Horellou, MH
    Flaujac, C
    Loriot, MA
    Samama, MM
    [J]. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2005, 3 (07) : 1533 - 1535
  • [2] A polymorphism in the VKORC1 gene is associated with an interindividual variability in the dose-anticoagulant effect of warfarin
    D'Andrea, G
    D'Ambrosio, RL
    Di Perna, P
    Chetta, M
    Santacroce, R
    Brancaccio, V
    Grandone, E
    Margaglione, M
    [J]. BLOOD, 2005, 105 (02) : 645 - 649
  • [3] Effects of CYP2C9 polymorphisms on the pharmacokinetics of R- and S-phenprocournon in healthy volunteers
    Kirchheiner, J
    Ufer, M
    Walter, EC
    Kammerer, B
    Kahlich, R
    Meisel, C
    Schwab, M
    Gleiter, CH
    Rane, A
    Roots, I
    Brockmöller, J
    [J]. PHARMACOGENETICS, 2004, 14 (01): : 19 - 26
  • [4] A gene-anchored map position of the rat warfarin-resistance locus, Rw, and its orthologs in mice and humans
    Kohn, MH
    Pelz, HJ
    [J]. BLOOD, 2000, 96 (05) : 1996 - 1998
  • [5] A coding VKORC1 Asp36Tyr polymorphism predisposes to warfarin resistance
    Loebstein, Ronen
    Dvoskin, Ilana
    Halkin, Hillel
    Vecsler, Manuela
    Lubetsky, Aharon
    Rechavi, Gideon
    Amariglio, Ninette
    Cohen, Yoram
    Ken-Dror, Gie
    Almog, Shlomo
    Gak, Eva
    [J]. BLOOD, 2007, 109 (06) : 2477 - 2480
  • [6] VKORC1:: molecular target of coumarins
    Oldenburg, J.
    Watzka, M.
    Rost, S.
    Mueller, C. R.
    [J]. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2007, 5 : 1 - 6
  • [7] HEREDITARY TRANSMISSION OF EXCEPTIONAL RESISTANCE TO COUMARIN ANTICOAGULANT DRUGS - FIRST REPORTED KINDRED
    OREILLY, RA
    LEONG, LS
    HOAG, MS
    AGGELER, PM
    KROPATKIN, ML
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1964, 271 (16) : 809 - +
  • [8] PETERSEN D, 1993, HAEMOSTASIS, V23, P83
  • [9] A C1173T dimorphism in the VKORC1 gene determines coumarin Sensitivity and bleeding risk
    Reitsma, PH
    van der Heijden, JF
    Groot, AP
    Rosendaal, FR
    Büller, HR
    [J]. PLOS MEDICINE, 2005, 2 (10) : 996 - 998
  • [10] Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose
    Rieder, MJ
    Reiner, AP
    Gage, BF
    Nickerson, DA
    Eby, CS
    McLeod, HL
    Blough, DK
    Thummel, KE
    Veenstra, DL
    Rettie, AE
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (22) : 2285 - 2293