'Naive' and 'memory' CD4+ T-cells and T-cell receptor (TCR) Vβ repertoire dynamics are independent of the levels of viremia following HIV seroconversion

被引：4

作者：

King, DJS

Amjadi, P

Tilling, R

Kinloch-de-Loes, S

Loveday, C

Johnson, MA

Janossy, G

Tarragona, A

Gotch, F

Larsson-Sciard, EL ^{[1
]}

机构：

[1] Chelsea & Westminster Hosp, ICSM, Dept Immunol, London SW10 9NH, England

[2] Royal Free Hosp, Dept Clin Immunol, London NW3 2QG, England

[3] Royal Free Hosp, Dept Retrovirol, London NW3 2QG, England

[4] Royal Free Hosp, Dept Thorac HIV Med, London NW3 2QG, England

[5] Charing Cross Hosp, ABC, ICSM, London W6 8RP, England

来源：

IMMUNOLOGY LETTERS | 1999年 / 66卷 / 1-3期

关键词：

primary HIV infection; CD4(+) T-cell repertoires; CD45RA(+); CD45RO(+); CDR3; spectratyping;

D O I：

10.1016/S0165-2478(98)00158-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The progression of 'naive' and 'memory' T-cells and the T-cell receptor V beta (TCR V beta) repertoire dynamics within the peripheral CD4(+) T-cell compartment were studied in individuals following HIV seroconversion. Profound TCR V beta repertoire perturbations were observed within the CD4(+) T-cell pool in treatment-naive patients regardless of their levels of viremia during the first 6-8 months after seroconversion. The ratio of 'naive' to 'memory' CD4(+) T-cells as well as the TCR V beta repertoire dynamics did not appear to correlate with absolute numbers of CD4(+) T-cells. (C) 1999 Elsevier Science B.V. All rights reserved.

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页码：199 / 206

页数：8

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