Psychological and behavioural impact of genetic testing smokers for lung cancer risk - A phase II exploratory trial

被引：52

作者：

Sanderson, Saskia C. ^{[1
]}

Humphries, Steve E. ^{[1
]}

Hubbart, Christina ^{[1
]}

Hughes, Eluned ^{[2
]}

Jarvis, Martin J. ^{[3
]}

Wardle, Jane ^{[3
]}

机构：

[1] UCL, British Heart Fdn Labs, Ctr Cardiovasc Genet, London WC1E 6JF, England

[2] Inst Child Hlth, London, England

[3] UCL, Canc Res UK Hlth Behav Res Ctr, Dept Epidemiol & Publ Hlth, London, England

来源：

JOURNAL OF HEALTH PSYCHOLOGY | 2008年 / 13卷 / 04期

基金：

英国经济与社会研究理事会;

关键词：

behaviour change; genetic testing; lung cancer; smoking cessation;

D O I：

10.1177/1359105308088519

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

The behavioural and psychological impact of genetic testing for lung cancer susceptibility was examined among smokers ( N = 61) who were randomly allocated to a GSTM1 genetic testing group ( with GSTM1-missing or GSTM1-present result) or no-test control group. The GSTM1-missing ( higher risk) group reported greater motivation to quit smoking, and both genetic testing groups reported lower depression than the control group at one-week follow-up ( p <.05 for all). Differences were not significant at two months follow-up. This study indicates the feasibility of much-needed research into the risks and benefits for individuals of emerging lifestyle-related genetic susceptibility tests.

引用

页码：481 / 494

页数：14

共 40 条

[1] Genetic susceptibility testing in smoking-cessation treatment: One-year outcomes of a randomized trial [J].

Audrain, J ;

Boyd, NR ;

Roth, J ;

Main, D ;

Caporaso, NE ;

Lerman, C .

ADDICTIVE BEHAVIORS, 1997, 22 (06) :741-751

[2] Meta- and pooled analyses of the effects of glutathione S-transferase M1 polymorphisms and smoking on lung cancer risk [J].

Benhamou, S ;

Lee, WJ ;

Alexandrie, AK ;

Boffetta, P ;

Bouchardy, C ;

Butkiewicz, D ;

Brockmöller, J ;

Clapper, ML ;

Daly, A ;

Dolzan, V ;

Ford, J ;

Gaspari, L ;

Haugen, A ;

Hirvonen, A ;

Husgafvel-Pursiainen, K ;

Ingelman-Sundberg, M ;

Kalina, I ;

Kihara, M ;

Kremers, P ;

Le Marchand, L ;

London, SJ ;

Nazar-Stewart, V ;

Onon-Kihara, M ;

Rannug, A ;

Romkes, M ;

Ryberg, D ;

Seidegard, J ;

Shields, P ;

Strange, RC ;

Stücker, I ;

To-Figueras, J ;

Brennan, P ;

Taioli, E .

CARCINOGENESIS, 2002, 23 (08) :1343-1350

[3] Intention to participate in predictive genetic testing for hereditary cancer: The role of attitude toward uncertainty [J].

Braithwaite, D ;

Sutton, S ;

Steggles, N .

PSYCHOLOGY & HEALTH, 2002, 17 (06) :761-772

[4] Genetic test evaluation: Information needs of clinicians, policy makers, and the public [J].

Burke, W ;

Atkins, D ;

Gwinn, M ;

Guttmacher, A ;

Haddow, J ;

Lau, J ;

Palomaki, G ;

Press, N ;

Richards, CS ;

Wideroff, L ;

Wiesner, GL .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2002, 156 (04) :311-318

[5] Framework for design and evaluation of complex interventions to improve health [J].

Campbell, M ;

Fitzpatrick, R ;

Haines, A ;

Kinmonth, AL ;

Sandercock, P ;

Spiegelhalter, D ;

Tyrer, P .

BRITISH MEDICAL JOURNAL, 2000, 321 (7262) :694-696

[6] Investigating the genetic determinants of cardiovascular disease using candidate genes and meta-analysis of association studies [J].

Casas, JP ;

Cooper, J ;

Miller, GJ ;

Hingorani, AD ;

Humphries, SE .

ANNALS OF HUMAN GENETICS, 2006, 70 :145-169

[7] A vision for the future of genomics research [J].

Collins, FS ;

Green, ED ;

Guttmacher, AE ;

Guyer, MS .

NATURE, 2003, 422 (6934) :835-847

[8] Motivations and psychosocial impact of genetic testing for HNPCC [J].

Esplen, MJ ;

Madlensky, L ;

Butler, K ;

McKinnon, W ;

Bapat, B ;

Wong, JH ;

Aronson, M ;

Gallinger, S .

AMERICAN JOURNAL OF MEDICAL GENETICS, 2001, 103 (01) :9-15

[9] The psychological complexity of predictive testing for late onset neurogenetic diseases and hereditary cancers: implications for multidisciplinary counselling and for genetic education [J].

Evers-Kiebooms, G ;

Welkenhuysen, M ;

Claes, E ;

Decruyenaere, M ;

Denayer, L .

SOCIAL SCIENCE & MEDICINE, 2000, 51 (06) :831-841

[10]

Field A, 2005, DISCOVERING STAT USI

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