Juvenile Dermatomyositis: Immunopathogenesis, Role of Myositis-Specific Autoantibodies, and Review of Rituximab Use

被引：28

作者：

Chiu, Yvonne E. ^{[1
]}

Co, Dominic O. ^{[2
]}

机构：

[1] Med Coll Wisconsin, Dept Dermatol, Div Pediat Dermatol, Milwaukee, WI 53226 USA

[2] Med Coll Wisconsin, Dept Pediat, Rheumatol Sect, Milwaukee, WI 53226 USA

来源：

PEDIATRIC DERMATOLOGY | 2011年 / 28卷 / 04期

关键词：

IDIOPATHIC INFLAMMATORY MYOPATHIES; PLASMACYTOID DENDRITIC CELLS; CLINICALLY AMYOPATHIC DERMATOMYOSITIS; SIGNAL RECOGNITION PARTICLE; INTERSTITIAL LUNG-DISEASE; REGULATORY T-CELLS; PERIPHERAL-BLOOD; AUTOIMMUNE-DISEASES; INFLAMED MUSCLE; POLYMYOSITIS;

D O I：

10.1111/j.1525-1470.2011.01501.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100227 [皮肤病学];

摘要：

Juvenile dermatomyositis (JDM) is an autoimmune disease of the skin and muscle that affects children. The etiology is poorly understood, but genetic susceptibility, environmental triggers, and abnormal immune responses are each thought to play a part. T cells have traditionally been implicated in the immunopathogenesis of JDM, but dendritic cells, B cells, and microchimerism are increasingly associated. Additionally, myositis-specific autoantibodies (MSA) can be present in the sera of affected patients and may correlate with distinct clinical phenotypes. Given the role of humoral immunity and MSA, there has been recent interest in the use of rituximab to treat JDM. Early results are mixed, but it is hoped that a prospective clinical trial will shed light on the issue in the near future.

引用

页码：357 / 367

页数：11

共 71 条

[1]

Altered cytokine expression of peripheral blood lymphocytes in polymyositis and dermatomyositis [J].

Aleksza, M ;

Szegedi, A ;

Antal-Szalmás, P ;

Irinyi, B ;

Gergely, L ;

Ponyi, A ;

Hunyadi, J ;

Sipka, S ;

Zeher, M ;

Szegedi, G ;

Dankó, K .

ANNALS OF THE RHEUMATIC DISEASES, 2005, 64 (10) :1485-1489

[2]

Role of Regulatory T Cells in a New Mouse Model of Experimental Autoimmune Myositis [J].

Allenbach, Yves ;

Solly, Sounkary ;

Gregoire, Sylvie ;

Dubourg, Odile ;

Salomon, Benoit ;

Butler-Browne, Gillian ;

Musset, Lucile ;

Herson, Serge ;

Klatzmann, David ;

Benveniste, Olivier .

AMERICAN JOURNAL OF PATHOLOGY, 2009, 174 (03) :989-998

[3]

[Anonymous], 2010, RIT

[4]

Persistent maternally derived peripheral microchimerism is associated with the juvenile idiopathic inflammatory myopathies [J].

Artlett, CM ;

Miller, FW ;

Rider, LG .

RHEUMATOLOGY, 2001, 40 (11) :1279-1284

[5]

Chimeric cells of maternal origin in juvenile idiopathic inflammatory myopathies [J].

Artlett, CM ;

Ramos, R ;

Jiminez, SA ;

Patterson, K ;

Miller, FW ;

Rider, LG .

LANCET, 2000, 356 (9248) :2155-2156

[6]

An interferon signature in the peripheral blood of dermatomyositis patients is associated with disease activity [J].

Baechler, Emily C. ;

Bauer, Jason W. ;

Slattery, Catherine A. ;

Ortmann, Ward A. ;

Espe, Karl J. ;

Novitzke, Jill ;

Ytterberg, Steven R. ;

Gregersen, Peter K. ;

Behrens, Timothy W. ;

Reed, Ann M. .

MOLECULAR MEDICINE, 2007, 13 (1-2) :59-68

[7]

Interleukin-6 and Type I Interferon-Regulated Genes and Chemokines Mark Disease Activity in Dermatomyositis [J].

Bilgic, Hatice ;

Ytterberg, Steven R. ;

Amin, Shreyasee ;

McNallan, Kelly T. ;

Wilson, Joseph C. ;

Koeuth, Thearith ;

Ellingson, Sonja ;

Newman, Brant ;

Bauer, Jason W. ;

Peterson, Erik J. ;

Baechler, Emily C. ;

Reed, Ann M. .

ARTHRITIS AND RHEUMATISM, 2009, 60 (11) :3436-3446

[8]

Autoantibody profiles in the sera of European patients with myositis [J].

Brouwer, R ;

Hengstman, GJD ;

Egberts, WV ;

Ehrfeld, H ;

Bozic, B ;

Ghirardello, A ;

Grondal, G ;

Hietarinta, M ;

Isenberg, D ;

Kalden, JR ;

Lundberg, I ;

Moutsopoulos, H ;

Roux-Lombard, P ;

Vencovsky, J ;

Wikman, A ;

Seelig, HP ;

van Engelen, BGM ;

van Venrooij, WJ .

ANNALS OF THE RHEUMATIC DISEASES, 2001, 60 (02) :116-123

[9]

Infiltrating cells, related cytokines and chemokine receptors in lesional skin of patients with dermatomyositis [J].

Caproni, M ;

Torchia, D ;

Cardinali, C ;

Volpi, W ;

Del Bianco, E ;

D'Agata, A ;

Fabbri, P .

BRITISH JOURNAL OF DERMATOLOGY, 2004, 151 (04) :784-791

[10]

Progressive multifocal leukoencephalopathy after rituximab therapy in HIV-negative patients: a report of 57 cases from the Research on Adverse Drug Events and Reports project [J].

Carson, Kenneth R. ;

Evens, Andrew M. ;

Richey, Elizabeth A. ;

Habermann, Thomas M. ;

Focosi, Daniele ;

Seymour, John F. ;

Laubach, Jacob ;

Bawn, Susie D. ;

Gordon, Leo I. ;

Winter, Jane N. ;

Furman, Richard R. ;

Vose, Julie M. ;

Zelenetz, Andrew D. ;

Mamtani, Ronac ;

Raisch, Dennis W. ;

Dorshimer, Gary W. ;

Rosen, Steven T. ;

Muro, Kenji ;

Gottardi-Littell, Numa R. ;

Talley, Robert L. ;

Sartor, Oliver ;

Green, David ;

Major, Eugene O. ;

Bennett, Charles L. .

BLOOD, 2009, 113 (20) :4834-4840

← 1 2 3 4 5 6 7 8 →