Determination of perfluorinated carboxylic acids in biological samples by high-performance liquid chromatography

被引：55

作者：

Ohya, T ^{[1
]}

Kudo, N ^{[1
]}

Suzuki, E ^{[1
]}

Kawashima, Y ^{[1
]}

机构：

[1] Josai Univ, Fac Pharmaceut Sci, Sakado, Saitama 3500295, Japan

来源：

JOURNAL OF CHROMATOGRAPHY B | 1998年 / 720卷 / 1-2期

关键词：

perfluorinated carboxylic acids;

D O I：

10.1016/S0378-4347(98)00448-4

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

This paper describes a method for the quantitative determination of perfluorinated carboxylic acids (PFCAs), perfluorohexanoic acid (C6-PFCA), perfluoroheptanoic acid (C7-PFCA), perfluorooctanoic acid (C8-PFCA), perfluorononanoic acid (C9-PFCA) and perfluorodecanoic acid (C10-PFCA), in biological samples. PFCA in liver homogenates was extracted as an ion pair with tetrabutylammonium (TBA) ion into organic solvent, then the PFCA. was derivatized with 3-bromoacetyl-7-methoxycoumarin (BrAMC) and quantified by HPLC with fluorescence detection. This method is applicable for the studies on tissue accumulation and elimination of PFCAs in animals after the administration. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：1 / 7

页数：7

共 12 条

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