Case-control study of environmental risk factors for Parkinson's disease in Belgium

被引：45

作者：

Pals, P

Van Everbroeck, B

Grubben, B

Viaene, MK

Dom, R

van der Linden, C

Santens, P

Martin, JJ

Cras, P

机构：

[1] Univ Instelling Antwerp, Born Bunge Fdn, Neurobiol Lab, B-2610 Wilrijk, Belgium

[2] Univ Antwerp Hosp, Dept Neurol, Edegem, Belgium

[3] Univ Hosp St Raphael, Dept Occupat Med, Neurotoxicol Sect, Louvain, Belgium

[4] Univ Hosp Gasthuisberg, Dept Neurol, B-3000 Louvain, Belgium

[5] AZ St Lucas Ziekenhuis, Dept Neurol, Brussels, Belgium

[6] State Univ Ghent Hosp, Dept Neurol, B-9000 Ghent, Belgium

[7] Univ Instelling Antwerp, Born Bunge Fdn, Neuropathol Lab, B-2610 Wilrijk, Belgium

来源：

EUROPEAN JOURNAL OF EPIDEMIOLOGY | 2003年 / 18卷 / 12期

关键词：

diet; gender; organophosphates and comorbidity; pesticides; smoking;

D O I：

10.1023/B:EJEP.0000006639.05690.92

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The aetiology of Parkinson's disease ( PD) is unknown and said to be multifactorial. We report on a retrospective epidemiological case control study, performed in Flanders during a 3- year period, investigating known and potential environmental risk factors for PD by means of questionnaires. We investigated 423 prevalent patients and 205 spouse-controls. We found familial occurrence in 15% of the patients, a mean age of onset of 58 years, and a clear male preponderance ( male/ female ratio 1.53). Our results suggest more nulliparity among female PD patients ( 95% CI: 1.08 - 5.76). We found a discrete clustering of patients in areas with intensive metallurgic activity. Patients were more frequently employed in metallurgy than controls ( 95% CI: 1.04 - 9.20). Furthermore, patients were clearly more exposed to zinc ( 95% CI: 1.51 - 90.90) and toluene ( 95% CI: 1.03 - 58.82). Male patients report more prostatectomy- surgery ( 95% CI: 1.54 - 17.24).

引用

页码：1133 / 1142

页数：10

共 41 条

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