Dynamics of cancer progression

被引：312

作者：

Michor, F

Iwasa, Y

Nowak, MA

机构：

[1] Harvard Univ, Program Evolutionary Dynam, Cambridge, MA 02138 USA

[2] Kyushu Univ, Dept Biol, Fukuoka 8128581, Japan

来源：

NATURE REVIEWS CANCER | 2004年 / 4卷 / 03期

关键词：

D O I：

10.1038/nrc1295

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Evolutionary concepts such as mutation and selection can be best described when formulated as mathematical equations. Cancer arises as a consequence of somatic evolution. Therefore, a mathematical approach can be used to understand the process of cancer initiation and progression. But what are the fundamental principles that govern the dynamics of activating oncogenes and inactivating tumour-suppressor genes in populations of reproducing cells? Also, how does a quantitative theory of somatic mutation and selection help us to evaluate the role of genetic instability?.

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页码：197 / 205

页数：9

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