Genetically destined potentials for N-linked glycosylation of influenza virus hemagglutinin

被引：81

作者：

Igarashi, Manabu ^{[1
]}

Ito, Kimihito ^{[1
]}

Kida, Hiroshi ^{[1
,2
]}

Takada, Ayato ^{[1
]}

机构：

[1] Hokkaido Univ, Res Ctr Zoonosis Control, Dept Global Epidemiol, Sapporo, Hokkaido 0010020, Japan

[2] Hokkaido Univ, Grad Sch Vet Med, Dept Dis Control, Sapporo, Hokkaido 0600818, Japan

来源：

VIROLOGY | 2008年 / 376卷 / 02期

关键词：

influenza A virus; hemagglutinin; N-glycosylation capacity; antigenic change; nucleotide sequence analysis; homology modeling; HA subtypes; prediction;

D O I：

10.1016/j.virol.2008.03.036

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The addition of oligosaccharide side chains to influenza virus hemagglutinin (HA) is believed to facilitate viral escape from immune pressure in the human population. To determine the implicit potentials for acquisition of N-linked glycosylation, we analyzed the genetic background of 16 subtypes of avian influenza virus, some of which may be potential pandemic viruses in the future. We found a significant difference among HA subtypes in their genomic sequences to produce N-glycosylation sites. Notably, recently circulating avian influenza viruses of the H5 and H9 subtypes may have rather greater capacities to undergo mutations associated with glycosylation of HA than past pandemic viruses. We hypothesize that influenza viruses maintained in natural reservoirs could have different potentials for sustained circulation, depending on their HA subtypes, if introduced into the human population. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：323 / 329

页数：7

共 34 条

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