New developments in photoprotection of human skin

被引:36
作者
Krutmann, J [1 ]
机构
[1] Univ Dusseldorf, Dept Dermatol, D-40225 Dusseldorf, Germany
来源
SKIN PHARMACOLOGY AND APPLIED SKIN PHYSIOLOGY | 2001年 / 14卷 / 06期
关键词
sunscreens; photoaging; photocarcinogenesis; ultraviolet radiation;
D O I
10.1159/000056374
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Because of increased leasure time, the growing popularity of staying outdoors and of holidays in the sun, it has become more and more important to study the molecular and photobiological effects that ultraviolet (UV) radiation exerts on human skin. Information obtained from these studies is being used to constantly improve the quality of sunscreen preparations containing organic and inorganic filters. It is also fostering the development of antioxidants and active agents that can be used in combination with or in addition to UV filters to provide better photoprotection for human skin. In addition, these studies provide novel test models which allow to prove or disprove the efficacy of a given sunscreen preparation for biological endpoints that differ from the sunburn reaction and are of direct relevance for photocarcinogenesis and photoaging. In this review, two examples are given to illustrate this development: (1) the use of topically applied DNA repair enzymes to prevent UVB-radiation-induced damage and (2) the development of a novel assay that is based on the detection of UVA-radiation-induced mutations in mitochondrial DNA and can be used to study the efficacy of protective measures against photoaging of human skin. Copyright (C) 2001 S. Karger AG, Basel.
引用
收藏
页码:401 / 407
页数:7
相关论文
共 19 条
[1]   Photocarcinogenesis and inhibition of intercellular adhesion molecule 1 expression in cells of DNA-repair-defective individuals [J].
Ahrens, C ;
Grewe, M ;
Berneburg, M ;
GretherBeck, S ;
Quilliet, X ;
Mezzina, M ;
Sarasin, A ;
Lehmann, AR ;
Arlett, CF ;
Krutmann, J .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (13) :6837-6841
[2]   MITOCHONDRIAL DECAY IN AGING [J].
AMES, BN ;
SHIGENAGA, MK ;
HAGEN, TM .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1995, 1271 (01) :165-170
[3]   Singlet oxygen mediates the UVA-induced generation of the photoaging-associated mitochondrial common deletion [J].
Berneburg, M ;
Grether-Beck, S ;
Kürten, V ;
Ruzicka, T ;
Briviba, K ;
Sies, H ;
Krutmann, J .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (22) :15345-15349
[4]   Chronically ultraviolet-exposed human skin shows a higher mutation frequency of mitochondrial DNA as compared to unexposed skin and the hematopoietic system [J].
Berneburg, M ;
Gattermann, N ;
Stege, H ;
Grewe, M ;
Vogelsang, K ;
Ruzicka, T ;
Krutmann, J .
PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1997, 66 (02) :271-275
[5]   Photoaging of human skin [J].
Berneburg, M ;
Plettenberg, H ;
Krutmann, J .
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE, 2000, 16 (06) :239-244
[6]  
BERNEBURG M, UNPUB PHOTOAGING ASS
[7]  
BERNEBURG M, UNPUB CREATINC SUPPL
[8]   Mitochondrial DNA deletions in human skin reflect photo rather than chronologic aging [J].
Birch-Machin, MA ;
Tindall, M ;
Turner, R ;
Haldane, F ;
Rees, JL .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1998, 110 (02) :149-152
[9]  
Brash DE, 1998, CANCER SURV, V32, P69
[10]  
CLEAVER J, 1968, NATURE, V372, P773