The role of the prefrontal cortex in object-place learning: a test of the attribute specificity model

被引:54
作者
Kesner, RP
Ragozzino, ME
机构
[1] Univ Utah, Dept Psychol, Salt Lake City, UT 84112 USA
[2] Univ Illinois, Dept Psychol, Chicago, IL 60607 USA
关键词
anterior cingulate; precentral; prelimbic;
D O I
10.1016/j.bbr.2003.09.024
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
In order to test an attribute specificity model of prefrontal cortex function, rats with lesions in the prelimbic-infralimbic (PL-IL) or anterior cingulate and precentral (AC-PC) subregions of the medial prefrontal cortex and controls were trained on an object-place paired associate task. Rats with AC-PC lesions acquired the task as readily as controls. In contrast, the PL-IL lesioned rats did not learn the task. Whenever higher order processing is required to solve a task, the data support an attribute-specificity model of prefrontal cortex function in that the PL-IL cortices support both object and place attribute information in a variety of tasks including object-place paired associate learning. (C) 2003 Elsevier B.V. All rights reserved.
引用
收藏
页码:159 / 165
页数:7
相关论文
共 55 条
[1]   Goal-directed instrumental action: contingency and incentive learning and their cortical substrates [J].
Balleine, BW ;
Dickinson, A .
NEUROPHARMACOLOGY, 1998, 37 (4-5) :407-419
[2]  
Birrell JM, 2000, J NEUROSCI, V20, P4320
[3]   Triple dissociation of anterior cingulate, posterior cingulate, and medial frontal cortices on visual discrimination tasks using a touchscreen testing procedure for the rat [J].
Bussey, TJ ;
Muir, JL ;
Everitt, BJ ;
Robbins, TW .
BEHAVIORAL NEUROSCIENCE, 1997, 111 (05) :920-936
[4]   RETENTION OF DELAYED-ALTERNATION - EFFECT OF SELECTIVE LESIONS OF SULCUS PRINCIPALIS [J].
BUTTERS, N ;
PANDYA, D .
SCIENCE, 1969, 165 (3899) :1271-&
[5]   MEMORY FOR SPATIAL LOCATION AS A FUNCTION OF TEMPORAL LAG IN RATS - ROLE OF HIPPOCAMPUS AND MEDIAL PREFRONTAL CORTEX [J].
CHIBA, AA ;
KESNER, RP ;
REYNOLDS, AM .
BEHAVIORAL AND NEURAL BIOLOGY, 1994, 61 (02) :123-131
[6]   Memory for temporal order of new and familiar spatial location Sequences: Role of the medial prefrontal cortex [J].
Chiba, AA ;
Kesner, RP ;
Gibson, CJ .
LEARNING & MEMORY, 1997, 4 (04) :311-317
[7]   Effects of selective thalamic and prelimbic cortex lesions on two types of visual discrimination and reversal learning [J].
Chudasama, Y ;
Bussey, TJ ;
Muir, JL .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2001, 14 (06) :1009-1020
[8]   Response learning of rats in a Morris water maze: Involvement of the medial prefrontal cortex [J].
deBruin, JPC ;
Swinkels, WAM ;
deBrabander, JM .
BEHAVIOURAL BRAIN RESEARCH, 1997, 85 (01) :47-55
[9]   A BEHAVIORAL-ANALYSIS OF RATS WITH DAMAGE TO THE MEDIAL PREFRONTAL CORTEX USING THE MORRIS WATER MAZE - EVIDENCE FOR BEHAVIORAL FLEXIBILITY, BUT NOT FOR IMPAIRED SPATIAL NAVIGATION [J].
DEBRUIN, JPC ;
SANCHEZSANTED, F ;
HEINSBROEK, RPW ;
DONKER, A ;
POSTMES, P .
BRAIN RESEARCH, 1994, 652 (02) :323-333
[10]   Short-term memory for food reward magnitude: The role of the prefrontal cortex [J].
DeCoteau, WE ;
Kesner, RP ;
Williams, JM .
BEHAVIOURAL BRAIN RESEARCH, 1997, 88 (02) :239-249