Peroxynitrite-scavenging activity of green tea tannin

被引：51

作者：

Chung, HY

Yokozawa, T ^{[1
]}

Soung, DY

Kye, IS

No, JK

Baek, BS

机构：

[1] Toyama Med & Pharmaceut Univ, Wakan Yaku Res Inst, Toyama 9300194, Japan

[2] Pusan Natl Univ, Coll Pharm, Gumjung Ku, Pusan 609735, South Korea

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 1998年 / 46卷 / 11期

关键词：

(-)-epigallocatechin 3-O-gallate; (-)-gallocatechin 3-O-gallate; green tea; peroxynitrite;

D O I：

10.1021/jf980556u

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Peroxynitrite formed from superoxide and nitric oxide acts as a strong reactive oxidant. However, among green tea components, catechins with a galloyl group inhibited peroxynitrite formation by 3-morpholinosydnonimine and scavenged peroxynitrite itself. Especially when compared with penicillamine as a positive control, the green tea components (-)-epigallocatechin 3-O-gallate and (-)-gallocatechin 3-O-gallate, which have two galloyl groups, showed the most potent peroxynitrite-scavenging activity, indicating that the galloyl group may contribute to this activity. A structure of flavan-3-ol linked to gallic acid may be essential for the peroxynitrite-scavenging activity.

引用

页码：4484 / 4486

页数：3

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