Synthesis and QSAR studies of 4-substituted phenyl-2,6-dimethyl-3, 5-bis-N-(substituted phenyl)carbamoyl-1,4-dihydropyridines as potential antitubercular agents

被引：130

作者：

Desai, B

Sureja, D

Naliapara, Y

Shah, A

Saxena, AK ^{[1
]}

机构：

[1] Saurashtra Univ, Dept Chem, Rajkot 360005, Gujarat, India

[2] Cent Drug Res Inst, Div Med Chem, Lucknow 226001, Uttar Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2001年 / 9卷 / 08期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0968-0896(01)00141-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Synthesis and QSAR studies of the title compounds have resulted in the identification of structural and physicochemical parameters (MR, sigma (o), sigma (m), sigma (p)) contributing to antitubercular activity. Among these, carbamoyl phenyl ring substituted at 3 and 4 position with NO2 group or 2 position with Cl or OCH3 group shows > 90% inhibition against H37R nu comparable to other substituted phenyls. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1993 / 1998

页数：6

共 12 条

[1]

ARNOLD M, 1998, J MED CHEM, V41, P2436

[2] TUBERCULOSIS - COMMENTARY ON A REEMERGENT KILLER [J].