Long-term potentiation and paired-pulse facilitation in the hippocampal CA1 region

被引：28

作者：

Asztely, F ^{[1
]}

Xiao, MY ^{[1
]}

Gustafsson, B ^{[1
]}

机构：

[1] UNIV GOTHENBURG,DEPT PHYSIOL & PHARMACOL,S-41320 GOTHENBURG,SWEDEN

来源：

NEUROREPORT | 1996年 / 7卷 / 10期

关键词：

synaptic plasticity; hippocampus; long-term potentiation; paired-pulse facilitation; release probability; adenosine agonist antagonists;

D O I：

10.1097/00001756-199607080-00016

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

WE have investigated the interaction between long-term potentiation (LTP) and paired-pulse facilitation (PPF) in the hippocampal CAI region under different conditions of initial PPF. PPF is a short lasting presynaptic alteration in synaptic efficacy, determined by the presynaptic release probability, where a high and low PPF indicate a low and high release probability, respectively. LTP was associated with no, or only little, change in PPF, independent of the initial value of PPF and of the time of measurement within the first hour of LTP. These results support the notion that the expression mechanism of LTP is not regulated by the initial release probability and that LTP is due to a single expression mechanism within its first hour.

引用

页码：1609 / 1612

页数：4

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