Stress and visceral pain: From animal models to clinical therapies

被引:165
作者
Larauche, Muriel [1 ,2 ,3 ]
Mulak, Agata [2 ,4 ]
Tache, Yvette [2 ,3 ]
机构
[1] Univ Calif Los Angeles, CURE Digest Dis Res Ctr, W Los Angeles VA Med Ctr, Los Angeles, CA 90073 USA
[2] Univ Calif Los Angeles, Ctr Neurobiol Stress, Div Digest Dis, Dept Med,David Geffen Sch Med, Los Angeles, CA 90073 USA
[3] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA
[4] Wroclaw Med Univ, Dept Gastroenterol & Hepatol, PL-50556 Wroclaw, Poland
关键词
Colorectal distension; CRF receptor; Irritable bowel syndrome; Mast cells; Stress; Visceral pain; IRRITABLE-BOWEL-SYNDROME; CORTICOTROPIN-RELEASING-FACTOR; NEONATAL MATERNAL SEPARATION; FUNCTIONAL GASTROINTESTINAL DISORDERS; RECEPTOR-MEDIATED MECHANISMS; ANTERIOR CINGULATE CORTEX; CENTRAL-NERVOUS-SYSTEM; DSS-INDUCED COLITIS; ROBALZOTAN TARTRATE MONOHYDRATE; PSEUDO-AFFECTIVE RESPONSES;
D O I
10.1016/j.expneurol.2011.04.020
中图分类号
Q189 [神经科学];
学科分类号
071006 [神经生物学];
摘要
Epidemiological studies have implicated stress (psychosocial and physical) as a trigger of first onset or exacerbation of irritable bowel syndrome (IBS) symptoms of which visceral pain is an integrant landmark. A number of experimental acute or chronic exteroceptive or interoceptive stressors induce visceral hyperalgesia in rodents although recent evidence also points to stress-related visceral analgesia as established in the somatic pain field. Underlying mechanisms of stress-related visceral hypersensitivity may involve a combination of sensitization of primary afferents, central sensitization in response to input from the viscera and dysregulation of descending pathways that modulate spinal nociceptive transmission or analgesic response. Biochemical coding of stress involves the recruitment of corticotropin releasing factor (CRF) signaling pathways. Experimental studies established that activation of brain and peripheral CRF receptor subtype 1 plays a primary role in the development of stress-related delayed visceral hyperalgesia while subtype 2 activation induces analgesic response. In line with stress pathways playing a role in IBS, nonpharmacologic and pharmacologic treatment modalities aimed at reducing stress perception using a broad range of evidence-based mind-body interventions and centrally-targeted medications to reduce anxiety impact on brain patterns activated by visceral stimuli and dampen visceral pain. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码:49 / 67
页数:19
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