From fish to man: understanding endogenous remyelination in central nervous system demyelinating diseases

被引:61
作者
Dubois-Dalcq, Monique [1 ]
Williams, Anna [2 ]
Stadelmann, Christine [3 ]
Stankoff, Bruno [4 ,5 ,6 ]
Zalc, Bernard [4 ,5 ,6 ]
Lubetzki, Catherine [4 ,5 ,6 ]
机构
[1] NINDS, Porter Neurosci Res Ctr, NIH, Bethesda, MD 20892 USA
[2] Western Gen Hosp, Dept Clin Neurosci, Edinburgh EH4 2XU, Midlothian, Scotland
[3] Univ Gottingen, Med Ctr, Inst Neuropathol, D-37075 Gottingen, Germany
[4] Univ Paris 06, INSERM, U711, F-75013 Paris, France
[5] Univ Paris 06, Fac Med, IFR 70, F-75252 Paris 05, France
[6] Hop La Pitie Salpetriere, AP HP, F-75013 Paris, France
关键词
multiple sclerosis; nodes of Ranvier; enhancing repair; animal models; transparent fish;
D O I
10.1093/brain/awn076
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
In the central nervous system (CNS) of man, evolutionary pressure has preserved some capability for remyelination while axonal regeneration is very limited. In contrast, two efficient programmes of regeneration exist in the adult fish CNS, neurite regrowth and remyelination. The rapidity of CNS remyelination is critical since it not only restores fast conduction of nerve impulses but also maintains axon integrity. If myelin repair fails, axons degenerate, leading to increased disability. In the human CNS demyelinating disease multiple sclerosis (MS), remyelination often takes place in the midst of inflammation. Here, we discuss recent studies that address the innate repair capabilities of the axon-glia unit from fish to man. We propose that expansion of this research field will help find ways to maintain or enhance spontaneous remyelination in man.
引用
收藏
页码:1686 / 1700
页数:15
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