Antitumor Effects of Interferon-Alpha on Cell Growth and Metastasis in Human Nasopharyngeal Carcinoma

被引：31

作者：

Liu, X. ^{[1
]}

Lu, J. ^{[1
]}

He, M. -L. ^{[2
,3
]}

Li, Z. ^{[4
]}

Zhang, B. ^{[5
]}

Zhou, L. -H. ^{[6
]}

Li, Q. ^{[1
]}

Li, G. ^{[1
]}

Wang, L. ^{[1
]}

Tian, W. -D. ^{[1
]}

Peng, Y. ^{[7
]}

Li, X. -P. ^{[1
]}

机构：

[1] So Med Univ, Nanfang Hosp, Dept Otolaryngol Head & Neck Surg, Guangzhou 510515, Guangdong, Peoples R China

[2] Chinese Univ Hong Kong, Sch Publ Hlth, Stanley Ho Ctr Emerging Infect Dis, Hong Kong, Hong Kong, Peoples R China

[3] Chinese Univ Hong Kong, Fac Med, Li Ka Shing Inst Hlth Sci, Hong Kong, Hong Kong, Peoples R China

[4] Shaanxi Normal Univ, Coll Life Sci, Mol Microbiol Lab, Xian 710062, Peoples R China

[5] So Med Univ, Inst Genet Engn, Guangzhou 510515, Guangdong, Peoples R China

[6] 150 Cent Hosp PLA, Dept Otolaryngol Head & Neck Surg, Luoyang 471037, Peoples R China

[7] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Neurol, Guangzhou 510120, Peoples R China

来源：

CURRENT CANCER DRUG TARGETS | 2012年 / 12卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Cell growth; cytokine; immunotherapy; interferon-alpha; 1b; metastasis; nasopharyngeal carcinoma; TUMOR-INFILTRATING LYMPHOCYTES; FACTOR RECEPTOR; I INTERFERON; IFN-ALPHA; T-CELLS; CANCER; EXPRESSION; SURVIVAL; PATHWAY; HEAD;

D O I：

10.2174/156800912800673293

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Nasopharyngeal carcinoma (NPC) is a highly malignant and frequently metastasized tumor, and the prognosis is very poor when distant metastases occur. Recently, immunotherapy is becoming a promising therapeutic approach. Interferon-alpha (IFN-alpha) represents the cytokines exhibiting the longest record of use in clinical oncology. In this study, we examined the antitumor effects of IFN-alpha 1b on NPC. The results showed that recombinant human IFN-alpha 1b (hIFN-alpha 1b) suppressed cell growth, induced a G1-phase cell cycle arrest in vitro, increased the expression of p16 and pRb, and decreased the expression of CCND1 and CDK6. In vivo analyses showed that either recombinant adeno-associated virus (rAAV)-IFN-alpha 1b or hIFN-alpha 1b treatment inhibited tumor growth and metastasis, reduced intratumoral microvessel density, increased cell apoptosis and necrosis, and induced prolonged survival. Notably, rAAV-IFN-alpha 1b or hIFN-alpha 1b treatment led to significantly higher serum levels of IL-12 and GM-CSF in mice compared to respective controls. Our findings suggest that IFN-alpha 1b acts as a multifunctional antitumor agent in NPC, which may have important therapeutic implications.

引用

页码：561 / 570

页数：10

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