Safety of DNA and modified vaccinia virus Ankara vaccines against liver-stage P-falciparum malaria in non-immune volunteers

被引：67

作者：

Moorthy, VS

McConkey, S

Roberts, M

Gothard, P

Arulanantham, N

Degano, P

Schneider, J

Hannan, C

Roy, M

Gilbert, SC

Peto, TEA

Hill, AVS

机构：

[1] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Med, Oxford OX3 9DU, England

[2] Powderject Vaccines, Madison, WI 53711 USA

来源：

VACCINE | 2003年 / 21卷 / 17-18期

关键词：

malaria; vaccine; safety;

D O I：

10.1016/S0264-410X(02)00771-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A series of phase I clinical studies were conducted to evaluate the safety of plasmid DNA and modified vaccinia virus Ankara malaria vaccines. The vaccines each encoded a polyepitope string fused to whole Plasmodium falciparum TRAP antigen. Forty-three healthy adult volunteers received the vaccines alone or in DNA/MVA prime-boost combinations. The DNA vaccine was administered either intramuscularly by needle or intradermally by a needleless delivery device. The MVA vaccine was administered intradermally by needle. The vaccines were well-tolerated by all three routes and in various DNA/MVA immunisation regimes. There were no severe or serious adverse events. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1995 / 2002

页数：8

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