Neoadjuvant endocrine therapy in primary breast cancer: indications and use as a research tool

被引：53

作者：

Chia, Y. H. ^{[1
]}

Ellis, M. J. ^{[1
,2
]}

Ma, C. X. ^{[1
,2
]}

机构：

[1] Washington Univ, Dept Med, Div Oncol, St Louis, MO 63110 USA

[2] Washington Univ, Siteman Canc Ctr, St Louis, MO 63110 USA

来源：

BRITISH JOURNAL OF CANCER | 2010年 / 103卷 / 06期

关键词：

breast cancer; oestrogen receptor; neoadjuvant endocrine therapy; genomics; relapse risk; POSTMENOPAUSAL PATIENTS; AROMATASE INHIBITOR; RANDOMIZED-TRIAL; ELDERLY-PATIENTS; TAMOXIFEN; LETROZOLE; ANASTROZOLE; COMBINATION; EXPRESSION; WOMEN;

D O I：

10.1038/sj.bjc.6605845

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Neoadjuvant endocrine therapy has been increasingly employed in clinical practice to improve surgical options for postmenopausal women with bulky hormone receptor-positive breast cancer. Recent studies indicate that tumour response in this setting may predict long-term outcome of patients on adjuvant endocrine therapy, which argues for its broader application in treating hormone receptor-positive disease. From the research perspective, neoadjuvant endocrine therapy provides a unique opportunity for studies of endocrine responsiveness and the development of novel therapeutic agents. British Journal of Cancer (2010) 103, 759-764. doi:10.1038/sj.bjc.6605845 www.bjcancer.com Published online 10 August 2010 (C) 2010 Cancer Research UK

引用

页码：759 / 764

页数：6

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