AB5 toxins:: structures and inhibitor design

被引：104

作者：

Fan, EK ^{[1
]}

Merritt, EA

Verlinde, CLMJ

Hol, WGJ

机构：

[1] Univ Washington, Dept Biol Struct, Biol Struct Ctr, Seattle, WA 98195 USA

[2] Univ Washington, Howard Hughes Med Inst, Seattle, WA 98195 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2000年 / 10卷 / 06期

关键词：

D O I：

10.1016/S0959-440X(00)00152-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

High-resolution crystal structures of AB(5) toxins in their native form or in complex with a variety of ligands have led to the structure-based design and discovery of inhibitors targeting different areas of the toxins. The most significant progress is the development of highly potent multivalent ligands that block binding of the toxins to their receptors.

引用

页码：680 / 686

页数：7

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