Elevated polymorphism and divergence in the class C scavenger receptors of Drosophila melanogaster and D-simulans

被引：55

作者：

Lazzaro, BP ^{[1
]}

机构：

[1] Cornell Univ, Dept Entomol, Ithaca, NY 14853 USA

来源：

GENETICS | 2005年 / 169卷 / 04期

关键词：

D O I：

10.1534/genetics.104.034249

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Scavenger receptor proteins are involved in the cellular internalization of a broad variety of foreign material, including pathogenic bacteria during phagocytosis. I find here that nonsynonymous divergence in three class C scavenger receptors (Sr-C's) between Drosophila melanogaster and D. simulans and between each of these species and D. yakuba is approximately four times the typical genome average. These genes also exhibit unusually high levels of segregating nonsynonymons polymorphism in D. melanogaster and D. simulans populations. A fourth Sr-C is comparatively conserved. McDonald-Kreitman tests reveal a significant excess of replacement fixations between D. melanogaster and D.simulans in the Sr-C's, but tests of polymorphic site frequency spectra do not support models of directional selection. It, is possible that the molecular functions of SR-C proteins are sufficiently robust to allow exceptionally high amino acid substitution rates without compromising organismal fitness. Alternatively, SR-Cs may evolve under diversifying selection, perhaps as a result of pressure from pathogens. Interestingly, Sr-CIII and Sr-CIV are polymorphic for premature stop codons. Sr-CIV is also polymorphic for an in-frame 101-codon deletion and for the absence of one intron.

引用

页码：2023 / 2034

页数：12

共 58 条

[1] MACROPHAGES IN DROSOPHILA EMBRYOS AND L2 CELLS EXHIBIT SCAVENGER RECEPTOR-MEDIATED ENDOCYTOSIS [J].

ABRAMS, JM ;

LUX, A ;

STELLER, H ;

KRIEGER, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (21) :10375-10379

[2] The genome sequence of Drosophila melanogaster [J].

Adams, MD ;

Celniker, SE ;

Holt, RA ;

Evans, CA ;

Gocayne, JD ;

Amanatides, PG ;

Scherer, SE ;

Li, PW ;

Hoskins, RA ;

Galle, RF ;

George, RA ;

Lewis, SE ;

Richards, S ;

Ashburner, M ;

Henderson, SN ;

Sutton, GG ;

Wortman, JR ;

Yandell, MD ;

Zhang, Q ;

Chen, LX ;

Brandon, RC ;

Rogers, YHC ;

Blazej, RG ;

Champe, M ;

Pfeiffer, BD ;

Wan, KH ;

Doyle, C ;

Baxter, EG ;

Helt, G ;

Nelson, CR ;

Miklos, GLG ;

Abril, JF ;

Agbayani, A ;

An, HJ ;

Andrews-Pfannkoch, C ;

Baldwin, D ;

Ballew, RM ;

Basu, A ;

Baxendale, J ;

Bayraktaroglu, L ;

Beasley, EM ;

Beeson, KY ;

Benos, PV ;

Berman, BP ;

Bhandari, D ;

Bolshakov, S ;

Borkova, D ;

Botchan, MR ;

Bouck, J ;

Brokstein, P .

SCIENCE, 2000, 287 (5461) :2185-2195

[3]

Andolfatto P, 2003, GENETICS, V165, P1289

[4] Contrasting patterns of X-linked and autosomal nucleotide variation in Drosophila melanogaster and Drosophila simulans [J].

Andolfatto, P .

MOLECULAR BIOLOGY AND EVOLUTION, 2001, 18 (03) :279-290

[5]

Andolfatto P, 2000, GENETICS, V156, P257

[6]

Begun DJ, 2000, GENETICS, V154, P1231

[7] AFRICAN AND NORTH-AMERICAN POPULATIONS OF DROSOPHILA-MELANOGASTER ARE VERY DIFFERENT AT THE DNA LEVEL [J].

BEGUN, DJ ;

AQUADRO, CF .

NATURE, 1993, 365 (6446) :548-550

[8] Protein variation in Drosophila simulans, and comparison of genes from centromeric versus noncentromeric regions of chromosome 3 [J].

Begun, DJ .

MOLECULAR BIOLOGY AND EVOLUTION, 2002, 19 (02) :201-203

[9] Reduced X-linked nucleotide polymorphism in Drosophila simulans [J].

Begun, DJ ;

Whitley, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (11) :5960-5965

[10] The cost of inbreeding in Arabidopsis [J].

Bustamante, CD ;

Nielsen, R ;

Sawyer, SA ;

Olsen, KM ;

Purugganan, MD ;

Hartl, DL .

NATURE, 2002, 416 (6880) :531-534

← 1 2 3 4 5 6 →