Release and formation of surface-localized ionic clusters (SLICs) into phospholipid rafts from colloidal solutions during coalescence

被引：16

作者：

Lestage, DJ ^{[1
]}

Urban, MW ^{[1
]}

机构：

[1] Univ So Mississippi, Sch Polymers & High Performance Mat, Shelby F Thames Polymer Res Ctr, Hattiesburg, MS 39406 USA

来源：

LANGMUIR | 2005年 / 21卷 / 06期

关键词：

D O I：

10.1021/la0475526

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Stimuli-responsive behavior of phospholipids in the presence of ionic surfactants utilized in synthesis of MMA/nBA colloidal particles was investigated. Utilizing 1-myristoyl-2-hydroxy-sn-glycero-phosphocholine (MHPC) phospholipid, and sodium dioctyl sulfosuccinate (SDOSS) surfactant as dispersing media in H2O, narrow unimodal particle size distributions of methyl methacrylate (MMA)/n-butylacrylate (nBA) copolymers were synthesized. The particle diameters were 154 nm when a SDOSS/MHPC mixture was used and 161 nm using MHPC as the only surface-stabilizing species. When such colloidal dispersions are exposed to 1.7, 3.3, and 6.7 mM aqueous CaCl2 and KCl electrolyte solutions, surface-localized ionic clusters are generated at the film-air interface that may serve as lipid rafts composed of crystalline phases of MHPC deposited on poly(MMA)/nBA films. These studies illustrate that it is possible to control release and morphology developments of surface phospholipid rafts on artificial surfaces.

引用

页码：2150 / 2157

页数：8

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