Effect of donepezil on brain acetylcholinesterase activity in patients with AD measured by PET

被引：75

作者：

Shinotoh, H

Aotsuka, A

Fukushi, K

Nagatsuka, S

Tanaka, N

Ota, T

Tanada, S

Irie, T

机构：

[1] Natl Inst Radiol Sci, Div Adv Technol Med Imaging, Inage Ku, Chiba 260, Japan

[2] Asahi Neurol Hosp, Chiba, Japan

[3] Chiba Univ, Sch Med, Dept Neurol, Chiba 280, Japan

[4] Daiichi Pure Chem Co Ltd, ADME TOX Res Inst, Ibaraki, Osaka, Japan

[5] Tokyo Womens Coll, Dept Neurosurg, Tokyo 162, Japan

[6] Juntendo Univ, Dept Psychiat, Tokyo, Japan

来源：

NEUROLOGY | 2001年 / 56卷 / 03期

关键词：

D O I：

10.1212/WNL.56.3.408

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Acetylcholinesterase (AChE) activities in the brain of three patients with AD were measured once before and once during donepezil treatment (5 mg/d in two patients, 3 mg/d in one patient) using PET and N-[C-11]methylpiperidin-4-yl acetate. Donepezil reduced k(3) values, an index of AChE activity, in the cerebral cortex by 39 +/- 5%. All patients showed some degree of symptomatic improvement, and it was concluded that this improvement was likely caused by improved cholinergic activity by inhibition of AChE in the brain.

引用

页码：408 / 410

页数：3

共 11 条

[1]

HUGHES CP, 1982, BRIT J PSYCHIAT, V140, P556

[2]

Irie T, 1996, J NUCL MED, V37, P649

[3] Measurement of acetylcholinesterase by positron emission tomography in the brains of healthy controls and patients with Alzheimer's disease [J].

Iyo, M ;

Namba, H ;

Fukushi, K ;

Shinotoh, H ;

Nagatsuka, S ;

Suhara, T ;

Sudo, Y ;

Suzuki, K ;

Irie, T .

LANCET, 1997, 349 (9068) :1805-1809

[4] In vivo mapping of cerebral acetylcholinesterase activity in aging and Alzheimer's disease [J].

Kuhl, DE ;

Koeppe, RA ;

Minoshima, S ;

Snyder, SE ;

Ficaro, EP ;

Foster, NL ;

Frey, KA ;

Kilbourn, MR .

NEUROLOGY, 1999, 52 (04) :691-699

[5]

MCKHANN G, 1984, NEUROLOGY, V34, P939, DOI 10.1212/WNL.34.7.939

[6] A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's disease [J].

Rogers, SL ;

Farlow, MR ;

Doody, RS ;

Mohs, R ;

Friedhoff, LT ;

Albala, B ;

Baumel, B ;

Booker, G ;

Dexter, J ;

Farmer, M ;

Feighner, JP ;

Ferris, S ;

Gordon, B ;

Gorman, DG ;

Hanna, G ;

Harrell, LE ;

Hubbard, R ;

Kennedy, J ;

McCarthy, J ;

Scharre, DW ;

Schaerf, F ;

Schneider, L ;

Seltzer, B ;

Siegal, A ;

Stark, SR ;

Strauss, A ;

Walshe, TM .

NEUROLOGY, 1998, 50 (01) :136-145

[7] The efficacy and safety of donepezil in patients with Alzheimer's disease: Results of a US multicentre, randomized, double-blind, placebo-controlled trial [J].

Rogers, SL ;

Friedhoff, LT ;

Apter, JT ;

Richter, RW ;

Hartford, JT ;

Walshe, TM ;

Baumel, B ;

Linden, RD ;

Kinney, FC ;

Doody, RS ;

Borison, RL ;

Ahem, GL .

DEMENTIA, 1996, 7 (06) :293-303

[8]

ROSEN WG, 1984, AM J PSYCHIAT, V141, P1356

[9]

Shinotoh H, 1999, ANN NEUROL, V46, P62

[10]

Shinotoh H, 2000, ANN NEUROL, V48, P194, DOI 10.1002/1531-8249(200008)48:2<194::AID-ANA9>3.0.CO

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