Rheological properties of contraceptive gels

被引：84

作者：

Owen, DH ^{[1
]}

Peters, JJ

Katz, DF

机构：

[1] Duke Univ, Dept Biomed Engn, Durham, NC 27706 USA

[2] Duke Univ, Dept Obstet & Gynecol, Durham, NC 27706 USA

来源：

CONTRACEPTION | 2000年 / 62卷 / 06期

关键词：

microbicide; contraceptive gel; vagina; rheology; viscosity;

D O I：

10.1016/S0010-7824(00)00184-0

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The rheological properties of 4 commercially available contraceptive drug delivery gels and their dilutions with a vaginal fluid simulant were measured. These properties govern the critical functions of spreading and retention of these gels over the vaginal surfaces. Measurements made on Conceptrol, KY Plus, Gynol TI, and Advantage-S included stress growth, stress relaxation and residual stress, and the shear rate dependence of viscosity. All gels exhibited non-Newtonian behavior including shear thinning and viscoelasticity. Conceptrol and Gynol II had no residual stress, while both KY Plus and Advantage-S did. The gels differed in their response to dilution with vaginal fluid simulant. (C) 2001 Elsevier Science Inc. All rights reserved.

引用

页码：321 / 326

页数：6