Cellular targets of interleukin-18 in rheumatoid arthritis

被引：40

作者：

Dai, Sheng-Ming

Shan, Zheng-Zheng

Xu, Huji

Nishioka, Kusuki

机构：

[1] Second Mil Med Univ, Changhai Hosp, Dept Rheumatol & Immunol, Shanghai 200433, Peoples R China

[2] Second Mil Med Univ, Changzheng Hosp, Dept Rheumatol & Immunol, Shanghai 200433, Peoples R China

[3] St Marianna Univ, Sch Med, Inst Med Sci, Dept Bioregulat, Kawasaki, Kanagawa, Japan

来源：

ANNALS OF THE RHEUMATIC DISEASES | 2007年 / 66卷 / 11期

关键词：

D O I：

10.1136/ard.2006.067793

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Recent data are presented which indicate a critical role for interleukin ( IL)- 18 in rheumatoid arthritis ( RA). The T cells and macrophages invading the synovium or in the synovial fluid are the chief cellular targets of IL- 18 in RA. Neutrophils, dendritic cells and endothelial cells may also be cellular mediators of IL-18. The direct effect of IL- 18 on fibroblast- like synoviocytes or chondrocytes may not be essential or important. In RA, IL- 18, which is mainly produced by macrophages, activates T cells and macrophages to produce proinflammatory cytokines, chemokines, adhesion molecules and RANKL which, in turn, perpetuate chronic inflammation and induce bone and cartilage destruction.

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收藏

页码：1411 / 1418

页数：8

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