Alternative binding assay of GP IIb/IIIa antagonists with a nonradioactive labeling method of platelets

被引：2

作者：

Alfón, J ^{[1
]}

de Arriba, AF ^{[1
]}

Gómez-Casajús, LA ^{[1
]}

Merlos, M ^{[1
]}

机构：

[1] J Uriach & Cia SA, Dept Pharmacol & Toxicol, Res Ctr, Barcelona 08026, Spain

来源：

THROMBOSIS RESEARCH | 2001年 / 102卷 / 03期

关键词：

D O I：

10.1016/S0049-3848(01)00255-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The method described in this paper is based on the adhesion of activated fluorescent-labeled PTLs to fibrinogen-coated plates. As summarized in Table 1, it constitutes a real alternative to the screening of GP IIb/IIIa antagonists performed by classical assays (radioactive and others). It reproducibly allows the screening of a high number of compounds and has been applied for the determination of GP IIb/IIIa antagonists activities.

引用

页码：247 / 253

页数：7

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