The Myc trilogy: lord of RNA polymerases

被引：103

作者：

Oskarsson, T ^{[1
]}

Trumpp, A ^{[1
]}

机构：

[1] Swiss Inst Expt Canc Res, CH-1066 Epalinges, Switzerland

来源：

NATURE CELL BIOLOGY | 2005年 / 7卷 / 03期

关键词：

D O I：

10.1038/ncb0305-215

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cancer cells have a raised cellular metabolism, including increased protein biosynthesis. Three new studies now show that the oncoprotein Myc, known to drive cell division, also enhances ribosomal RNA synthesis by RNA polymerase I in addition to controlling RNA polymerase II- and III-regulated gene transcription. This suggests that Myc promotes the generation of crucial components of a functional ribosome.

引用

页码：215 / 217

页数：3

共 23 条

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